TY - JOUR
T1 - Both diabetes and fetuin-A are independently associated with increased risk of arterial stiffness
AU - Ou, Horng Yih
AU - Lu, Feng Hwa
AU - Wu, Hung Tsung
AU - Hung, Hao Chang
AU - Wu, Jin Shang
AU - Yang, Yi Ching
AU - Chang, Chih Jen
N1 - Publisher Copyright:
© 2015 Elsevier B.V.
PY - 2015/5/1
Y1 - 2015/5/1
N2 - Background: Arterial stiffness is a functional assessment of vascular damage caused by cardiovascular disease (CVD) risk factors. Fetuin-A is associated with subclinical CVD and incident or fatal CVD, with some modification of its effect occurring with the presence of diabetes. We investigated the impact of different glycemic statuses and serum fetuin-A levels on arterial stiffness. Methods: A total of 312 age- and sex-matched subjects with normal glucose tolerance (NGT), impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and newly diagnosed diabetes (NDD) were recruited. Serum fetuin-A levels were measured, and arterial stiffness was assessed by brachial-ankle pulse-wave velocity (baPWV). Results: We found that the mean values of baPWV were 1533 ± 338, 1518 ± 353, 1589 ± 307, and 1690 ± 414. cm/s, and fetuin-A levels were 298 ± 69, 313 ± 67, 330 ± 86, and 342 ± 93. μg/ml, in subjects with NGT, IFG, IGT, and NDD, respectively (both p < 0.001, test for trend). NDD subjects had significantly higher baPWV and fetuin-A levels than those with NGT. Multiple linear regression analysis showed that age, fetuin-A, diabetes, hypertension, and hypertriglyceridemia are independently associated factors of baPWV after adjusting for cardiometabolic risk factors, HOMA-IR, and adiponectin. Conclusion: Both diabetes and fetuin-A levels are independently associated with arterial stiffness. Fetuin-A may further aggravate increased arterial stiffness in diabetes.
AB - Background: Arterial stiffness is a functional assessment of vascular damage caused by cardiovascular disease (CVD) risk factors. Fetuin-A is associated with subclinical CVD and incident or fatal CVD, with some modification of its effect occurring with the presence of diabetes. We investigated the impact of different glycemic statuses and serum fetuin-A levels on arterial stiffness. Methods: A total of 312 age- and sex-matched subjects with normal glucose tolerance (NGT), impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and newly diagnosed diabetes (NDD) were recruited. Serum fetuin-A levels were measured, and arterial stiffness was assessed by brachial-ankle pulse-wave velocity (baPWV). Results: We found that the mean values of baPWV were 1533 ± 338, 1518 ± 353, 1589 ± 307, and 1690 ± 414. cm/s, and fetuin-A levels were 298 ± 69, 313 ± 67, 330 ± 86, and 342 ± 93. μg/ml, in subjects with NGT, IFG, IGT, and NDD, respectively (both p < 0.001, test for trend). NDD subjects had significantly higher baPWV and fetuin-A levels than those with NGT. Multiple linear regression analysis showed that age, fetuin-A, diabetes, hypertension, and hypertriglyceridemia are independently associated factors of baPWV after adjusting for cardiometabolic risk factors, HOMA-IR, and adiponectin. Conclusion: Both diabetes and fetuin-A levels are independently associated with arterial stiffness. Fetuin-A may further aggravate increased arterial stiffness in diabetes.
KW - Arterial stiffness
KW - Diabetes
KW - Fetuin-A
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U2 - 10.1016/j.cca.2015.03.030
DO - 10.1016/j.cca.2015.03.030
M3 - Article
C2 - 25841642
AN - SCOPUS:84926313368
SN - 0009-8981
VL - 445
SP - 133
EP - 138
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
ER -