Bone marrow involvement as the initial presentation of hodgkin's lymphoma is undetectable by18F-fluorodeoxyglucose positron emission tomography/computed tomography

Chun Chi Lu, Cheng Yi Cheng, Tsu Yi Chao, Ching Liang Ho

研究成果: 雜誌貢獻文章同行評審

摘要

We report a 28-year-old male who presented with fever and bone pain without peripheral lymphadenopathy observed during initial physical examination. Subsequent bone marrow examination revealed the presence of Reed-Sternberg (RS) cells, which led to a diagnosis of mixed cellularity subtype of Hodgkin's lymphoma (HL). However, the initial 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) scan did not show any detectable marrow or nodal lesions, with the exception of FDG uptake in an extranodal lesion over the right adrenal gland. Two weeks later, a 2-cm enlarged lymph node over the left submandibular region appeared. Excisional biopsy revealed HL. Mixed cellularity subtype of stage IV HL with initial bone marrow and unilateral adrenal gland involvement followed by submandibular lymphadenopathy was diagnosed, according to clinical, imaging, and histological manifestations. This patient received six cycles of chemotherapy with regimen of doxorubincin, bleomycin, vinblastine, and decabazine (ABVD). The subsequent FDG-PET/CT scan revealed complete remission after chemotherapy.

原文英語
頁(從 - 到)209-212
頁數4
期刊Journal of Medical Sciences (Taiwan)
28
發行號5
出版狀態已發佈 - 2008
對外發佈

ASJC Scopus subject areas

  • 一般醫學

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