TY - JOUR
T1 - Bombesin-induced hypothermia
T2 - Possible involvement of cholinergic and dopaminergic receptors in the rat hypothalamus
AU - Chiu, Wen Ta
AU - Lin, Lieh Shen
AU - Shih, Chun Jen
AU - Lin, Mao Tsun
PY - 1987/2
Y1 - 1987/2
N2 - The thermal responses of rats which were pretreated with 5,7-dihydroxytryptamine to deplete hypothalamic 5-hydroxytryptamine, 6-hydroxydopamine to deplete hypothalamic catecholamines, phentolamine and propranolol to inhibit adrenergic receptors, haloperidol to inhibit dopamine receptors, or atropine to inhibit cholinergic receptors, to intrahypothalamic administration of bombesin were compared with those of control rats. The bombesin-induced hypothermia was attenuated by pretreatment of the rats with either hypothalamic dopamine depletion or receptor blockade, or hypothalamic cholinergic receptor blockade. The reduction in the bombesin-induced hypothermia in the treated rats was due to the reduction of metabolic and vasomotor response. The data indicate that bombesin may act on hypothalamic dopamine and/or cholinergic receptor mechanisms to induce hypothermia by promoting a reduction in metabolic heat production and an enhancement in heat loss in rats.
AB - The thermal responses of rats which were pretreated with 5,7-dihydroxytryptamine to deplete hypothalamic 5-hydroxytryptamine, 6-hydroxydopamine to deplete hypothalamic catecholamines, phentolamine and propranolol to inhibit adrenergic receptors, haloperidol to inhibit dopamine receptors, or atropine to inhibit cholinergic receptors, to intrahypothalamic administration of bombesin were compared with those of control rats. The bombesin-induced hypothermia was attenuated by pretreatment of the rats with either hypothalamic dopamine depletion or receptor blockade, or hypothalamic cholinergic receptor blockade. The reduction in the bombesin-induced hypothermia in the treated rats was due to the reduction of metabolic and vasomotor response. The data indicate that bombesin may act on hypothalamic dopamine and/or cholinergic receptor mechanisms to induce hypothermia by promoting a reduction in metabolic heat production and an enhancement in heat loss in rats.
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U2 - 10.1016/0014-4886(87)90145-2
DO - 10.1016/0014-4886(87)90145-2
M3 - Article
C2 - 2879738
AN - SCOPUS:0023139789
SN - 0014-4886
VL - 95
SP - 368
EP - 377
JO - Experimental Neurology
JF - Experimental Neurology
IS - 2
ER -