TY - JOUR
T1 - Blood copper and zinc levels and copper-related antioxidant enzyme activities in hypercholesterolemic subjects
AU - Hu, Xue Ping
AU - Hsu, Chang Yun
AU - Hsieh, Ming Che
PY - 1997
Y1 - 1997
N2 - Hypercholesterolemia has been shown to be a consequence of dietary copper (Cu) deficiency in experimental animals. There are several biochemical changes induced by Cu deficiency. We examined the lipid level, superoxide dismutase (SOD), glutathione peroxidase (GSHPx), ceruloplasmin (Cp) and plasma Cu and Zn levels in hypercholesterolemic subjects (N=23, total cholesterol (TC)≤ 240 mg/dL); borderline hypercholesterolemic subjects (N=31, 200 ≤ TC <240 mg/dL) and control subjects (N=25, TC <200 mg/dL). Total cholesterol, triglyceride (TG), and low density lipoprotein (LDL-C) levels were higher in hypercholesterolemic subjects than in the normal subjects (p <0.05). Hypercholesterolemic subjects had lower Cu levels than the control subjects (p <0.05). The SOD, Cp, and Zn levels in the hypercholesterolemic subjects did not significantly differ from those in the control group. Lipid levels were not related to plasma Cu, SOD, and Cp among the three groups. Plasma GSHPx levels were positively correlated with SOD and Cp values in the control subjects (r= 0.40, r=0.45, p
AB - Hypercholesterolemia has been shown to be a consequence of dietary copper (Cu) deficiency in experimental animals. There are several biochemical changes induced by Cu deficiency. We examined the lipid level, superoxide dismutase (SOD), glutathione peroxidase (GSHPx), ceruloplasmin (Cp) and plasma Cu and Zn levels in hypercholesterolemic subjects (N=23, total cholesterol (TC)≤ 240 mg/dL); borderline hypercholesterolemic subjects (N=31, 200 ≤ TC <240 mg/dL) and control subjects (N=25, TC <200 mg/dL). Total cholesterol, triglyceride (TG), and low density lipoprotein (LDL-C) levels were higher in hypercholesterolemic subjects than in the normal subjects (p <0.05). Hypercholesterolemic subjects had lower Cu levels than the control subjects (p <0.05). The SOD, Cp, and Zn levels in the hypercholesterolemic subjects did not significantly differ from those in the control group. Lipid levels were not related to plasma Cu, SOD, and Cp among the three groups. Plasma GSHPx levels were positively correlated with SOD and Cp values in the control subjects (r= 0.40, r=0.45, p
KW - Ceruloplasmin
KW - Copper
KW - GSHPx
KW - Hypercholesterolemia
KW - SOD
KW - Zinc
UR - http://www.scopus.com/inward/record.url?scp=0030881027&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030881027&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0030881027
SN - 1011-6958
VL - 22
SP - 277
EP - 285
JO - Nutritional Sciences Journal
JF - Nutritional Sciences Journal
IS - 3
ER -