Blood-based omic profiling supports female susceptibility to tobacco smoke-induced cardiovascular diseases

Aristotelis Chatziioannou, Panagiotis Georgiadis, Dennie G. Hebels, Irene Liampa, Ioannis Valavanis, Ingvar A. Bergdahl, Anders Johansson, Domenico Palli, Marc Chadeau-Hyam, Alexandros P. Siskos, Hector Keun, Maria Botsivali, Theo M.C.M. De Kok, Almudena Espín Pérez, Jos C.S. Kleinjans, Paolo Vineis, Soterios A. Kyrtopoulos, Ralph Gottschalk, Danitsja Van Leeuwen, Leen TimmermansBenedetta Bendinelli, Rachel Kelly, Roel Vermeulen, Lutzen Portengen, Fatemeh Saberi-Hosnijeh, Beatrice Melin, Goran Hallmans, Per Lenner, Toby J. Athersuch, Manolis Kogevinas, Euripides G. Stephanou, Antonis Myridakis, Lucia Fazzo, Marco De Santis, Pietro Comba, Hannu Kiviranta, Panu Rantakokko, Riikka Airaksinen, Paivi Ruokojarvi, Mark Gilthorpe, Sarah Fleming, Thomas Fleming, Yu Kang Tu, Bo Jonsson, Thomas Lundh, Wei J. Chen, Wen Chung Lee, Chuhsing Kate Hsiao, Kuo Liong Chien, Po Hsiu Kuo, Hung Hung, Shu Fen Liao

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16 引文 斯高帕斯(Scopus)


We recently reported that differential gene expression and DNA methylation profiles in blood leukocytes of apparently healthy smokers predicts with remarkable efficiency diseases and conditions known to be causally associated with smoking, suggesting that blood-based omic profiling of human populations may be useful for linking environmental exposures to potential health effects. Here we report on the sex-specific effects of tobacco smoking on transcriptomic and epigenetic features derived from genome-wide profiling in white blood cells, identifying 26 expression probes and 92 CpG sites, almost all of which are affected only in female smokers. Strikingly, these features relate to numerous genes with a key role in the pathogenesis of cardiovascular disease, especially thrombin signaling, including the thrombin receptors on platelets F2R (coagulation factor II (thrombin) receptor; PAR1) and GP5 (glycoprotein 5), as well as HMOX1 (haem oxygenase 1) and BCL2L1 (BCL2-like 1) which are involved in protection against oxidative stress and apoptosis, respectively. These results are in concordance with epidemiological evidence of higher female susceptibility to tobacco-induced cardiovascular disease and underline the potential of blood-based omic profiling in hazard and risk assessment.
期刊Scientific Reports
出版狀態已發佈 - 2月 2017

ASJC Scopus subject areas

  • 多學科


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