BK virus as a potential oncovirus for bladder cancer in a renal transplant patient

Wen Yao Yin, Ming Che Lee, Ning Sheng Lai, Ming Chi Lu

研究成果: 雜誌貢獻文章同行評審

18 引文 斯高帕斯(Scopus)


Renal transplant patients have high risk for bladder cancer. The reactivation of BK virus is common in renal transplant patients especially in the urinary tract. There was some evidence suggesting that the reactivation of BK virus (BKV) in renal transplant patients may associate with the development of bladder cancer. Here we demonstrated that a patient that had persistent elevated BKV viruria (urine BKV DNA concentration more than 1011 copies/ml) after renal transplantation. Then, bladder cancer was found in 13 months after kidney transplantation. The urine BKV DNA concentration was detected by real-time PCR and the BKV DNA in the bladder tumor was detected by PCR. BKV DNA was found in the marginal and central part of the bladder tumor. After removal of the bladder cancer, the urine BKV viral load in this patients dropped dramatically to <102 copies/ml. However, the urine viral load had increased modestly to 106 copies/ml in 3 months after surgery. Since there is a close correlation between the urine BK viral load and the presence of bladder cancer, we suggested that there might be a causal relationship between the reactivation of BKV and the development of bladder cancer in renal transplant patient.

頁(從 - 到)373-374
期刊Journal of the Formosan Medical Association
出版狀態已發佈 - 4月 1 2015

ASJC Scopus subject areas

  • 一般醫學


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