Bipolar symptoms, somatic burden and functioning in older-age bipolar disorder: A replication study from the global aging & geriatric experiments in bipolar disorder database (GAGE-BD) project

Martha Sajatovic, Soham Rej, Osvaldo P. Almeida, Kursat Altinbas, Vicent Balanzá-Martínez, Izabela G. Barbosa, Alexandra J.M. Beunders, Hilary P. Blumberg, Farren B.S. Briggs, Annemiek Dols, Brent P. Forester, Orestes V. Forlenza, Ariel G. Gildengers, Esther Jimenez, Federica Klaus, Beny Lafer, Benoit Mulsant, Benson Mwangi, Paula Villela Nunes, Andrew T. OlagunjuStephen Oluwaniyi, Melis Orhan, Regan E. Patrick, Joaquim Radua, Tarek Rajji, Kaylee Sarna, Sigfried Schouws, Christian Simhandl, Harmehr Sekhon, Jair C. Soares, Ashley N. Sutherland, Antonio L. Teixeira, Shangying Tsai, Sonia Vidal-Rubio, Eduard Vieta, Joy Yala, Lisa T. Eyler

研究成果: 雜誌貢獻文章同行評審

4 引文 斯高帕斯(Scopus)

摘要

Objectives: The Global Aging & Geriatric Experiments in Bipolar Disorder Database (GAGE-BD) project pools archival datasets on older age bipolar disorder (OABD). An initial Wave 1 (W1; n = 1369) analysis found both manic and depressive symptoms reduced among older patients. To replicate this finding, we gathered an independent Wave 2 (W2; n = 1232, mean ± standard deviation age 47.2 ± 13.5, 65% women, 49% aged over 50) dataset. Design/Methods: Using mixed models with random effects for cohort, we examined associations between BD symptoms, somatic burden and age and the contribution of these to functioning in W2 and the combined W1 + W2 sample (n = 2601). Results: Compared to W1, the W2 sample was younger (p < 0.001), less educated (p < 0.001), more symptomatic (p < 0.001), lower functioning (p < 0.001) and had fewer somatic conditions (p < 0.001). In the full W2, older individuals had reduced manic symptom severity, but age was not associated with depression severity. Age was not associated with functioning in W2. More severe BD symptoms (mania p ≤ 0.001, depression p ≤ 0.001) were associated with worse functioning. Older age was significantly associated with higher somatic burden in the W2 and the W1 + W2 samples, but this burden was not associated with poorer functioning. Conclusions: In a large, independent sample, older age was associated with less severe mania and more somatic burden (consistent with previous findings), but there was no association of depression with age (different from previous findings). Similar to previous findings, worse BD symptom severity was associated with worse functioning, emphasizing the need for symptom relief in OABD to promote better functioning.

原文英語
文章編號e6057
期刊International Journal of Geriatric Psychiatry
39
發行號3
DOIs
出版狀態已發佈 - 3月 2024

ASJC Scopus subject areas

  • 老年病學和老年學
  • 精神病學和心理健康

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