Biomaterial-induced conversion of quiescent cardiomyocytes into pacemaker cells in rats

Yu Feng Hu, An Sheng Lee, Shih Lin Chang, Shien Fong Lin, Ching Hui Weng, Hsin Yu Lo, Pei Chun Chou, Yung Nan Tsai, Yen Ling Sung, Chien Chang Chen, Ruey Bing Yang, Yuh Charn Lin, Terry B.J. Kuo, Cheng Han Wu, Jin Dian Liu, Tze Wen Chung, Shih Ann Chen

研究成果: 雜誌貢獻文章同行評審

14 引文 斯高帕斯(Scopus)


Pacemaker cells can be differentiated from stem cells or transdifferentiated from quiescent mature cardiac cells via genetic manipulation. Here we show that the exposure of rat quiescent ventricular cardiomyocytes to a silk-fibroin hydrogel activates the direct conversion of the quiescent cardiomyocytes to pacemaker cardiomyocytes by inducing the ectopic expression of the vascular endothelial cell-adhesion glycoprotein cadherin. The silk-fibroin-induced pacemaker cells exhibited functional and morphological features of genuine sinoatrial-node cardiomyocytes in vitro, and pacemaker cells generated via the injection of silk fibroin in the left ventricles of rats functioned as a surrogate in situ sinoatrial node. Biomaterials with suitable surface structure, mechanics and biochemistry could facilitate the scalable production of biological pacemakers for human use.
頁(從 - 到)421-434
期刊Nature Biomedical Engineering
出版狀態已發佈 - 4月 2022

ASJC Scopus subject areas

  • 生物技術
  • 生物工程
  • 醫藥(雜項)
  • 生物醫學工程
  • 電腦科學應用


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