TY - JOUR
T1 - Biological roles of CCAAT/enhancer-binding protein delta during inflammation
AU - Ko, Chiung Yuan
AU - Chang, Wen Chang
AU - Wang, Ju Ming
N1 - Publisher Copyright:
© 2015 Ko et al.; licensee BioMed Central.
PY - 2015/1/16
Y1 - 2015/1/16
N2 - CCAAT/enhancer-binding protein delta (CEBPD) belongs to the CCAAT/enhancer-binding protein family, and these proteins function as transcription factors in many biological processes, including cell differentiation, motility, growth arrest, proliferation, cell death, metabolism and immune responses. The functional diversity of CEBPD depends, in part, on the cell type and cellular context, which indicates that CEBPD could interpret a variety of cues to adjust cellular responses in specific situations. Here, we review the regulation of the CEBPD gene and its function in response to inflammatory stimuli. We also address its effects in inflammation-related diseases through a discussion of its recently discovered downstream targets. Regarding to the previous discoveries and new insights in inflammation-associated diseases, suggesting CEBPD could also be a central gene in inflammation. Importantly, the results of this study indicate that the investigation of CEBPD could open a new avenue to help better understand the inflammatory response.
AB - CCAAT/enhancer-binding protein delta (CEBPD) belongs to the CCAAT/enhancer-binding protein family, and these proteins function as transcription factors in many biological processes, including cell differentiation, motility, growth arrest, proliferation, cell death, metabolism and immune responses. The functional diversity of CEBPD depends, in part, on the cell type and cellular context, which indicates that CEBPD could interpret a variety of cues to adjust cellular responses in specific situations. Here, we review the regulation of the CEBPD gene and its function in response to inflammatory stimuli. We also address its effects in inflammation-related diseases through a discussion of its recently discovered downstream targets. Regarding to the previous discoveries and new insights in inflammation-associated diseases, suggesting CEBPD could also be a central gene in inflammation. Importantly, the results of this study indicate that the investigation of CEBPD could open a new avenue to help better understand the inflammatory response.
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U2 - 10.1186/s12929-014-0110-2
DO - 10.1186/s12929-014-0110-2
M3 - Review article
C2 - 25591788
AN - SCOPUS:84927933276
SN - 1021-7770
VL - 22
JO - Journal of Biomedical Science
JF - Journal of Biomedical Science
IS - 1
M1 - 6
ER -