Bioactive Y-lactones from the fermented broth of neosartorya sp.

Sien Sing Yang, Guei Jane Wang, Kuo Fang Cheng, Chu Huang Chen, Yu Ming Ju, Ya Jing Tsau, Zong-Huei Li

研究成果: 雜誌貢獻文章同行評審

6 引文 斯高帕斯(Scopus)


Two Y-lactone derivatives, namely neosartolactone (1) and its 7-methyl ester analogue (2), have been isolated from the ethyl acetate extract of the fermented broth of Neosartorya sp. isolated in Taiwan. Structural elucidations of compounds 1 and 2 were achieved on the basis of spectroscopic analysis. Although they had been obtained via the chemical modification of avenaciolide isolated from Aspergillus avenaceus several decades ago, this is the first report to describe them from a natural resource with detailed spectroscopic interpretations. The effects of 1 and 2 on the inhibition of NO production in lipopolysaccharide (LPS)-activated murine macrophages were further evaluated. Compounds 1 and 2 significantly inhibited NO production with the IC50 values of 12.2±1.5 and 11.4±1.0μ M, respectively; but displayed cytotoxicity at considerably higher concentrations than 50μ M.
頁(從 - 到)1701-1705
期刊Planta Medica
出版狀態已發佈 - 2010

ASJC Scopus subject areas

  • 補充和替代醫學
  • 分子醫學
  • 有機化學
  • 分析化學
  • 藥學科學
  • 藥理
  • 藥物發現


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