@article{fca6b8b8dfd34ea3ab656c5a6cef7aba,
title = "Bioactive Triterpenoids from the Leaves and Twigs of Lithocarpus litseifolius and L corneus",
abstract = "Phytochemical investigation of the leaves and twigs of Lithocarpus litseifolius and Lithocarpus corneus resulted in the isolation of four new triterpenoids (1 - 4), three triterpenoids (5 - 7) isolated from a natural source for the first time, and six known compounds (8 - 13). In addition, four known triterpenoids (14 - 17) were isolated from L. corneus. Compound 1 is a 3,4- seco -lupane-type triterpenoid, and compounds 2 - 4 are lupane-type triterpenoids in different oxidation states. The structures of all isolated compounds were identified by spectroscopic methods, especially NMR and mass spectrometry data. The absolute configuration of 2 and 3 was confirmed by X-ray single crystallographic analysis. The anti-inflammatory activities of 1 - 17 and anti-HIV activities of 2 - 17 were evaluated. Among them, 3- epi -betulinic acid (8) showed a strong anti-HIV activity comparable to abacavir, a drug used for treating HIV/AIDS. 3,4- seco -4(23),20(29)-lupadiene-3,28-dioic acid (5) exhibited potent inhibition of superoxide-anion generation with 86.9 ± 2.8% inhibition at 1 μM.",
keywords = "anti-HIV, anti-inflammatory, Fagaceae, Lithocarpus corneus, Lithocarpus litseifolius, triterpenoids",
author = "Cheng, {Yuan Bin} and Liu, {Fan Jin} and Wang, {Chih Hsin} and Hwang, {Tsong Long} and Tsai, {Yung Fong} and Yen, {Chia Hung} and Wang, {Hui Chun} and Tseng, {Yen Hsueh} and Chien, {Ching Te} and Chen, {Yi Ming Arthur} and Chang, {Fang Rong} and Wu, {Yang Chang}",
note = "Funding Information: This work was supported by grants from the Ministry of Science and Technology of Taiwan (MOST103-2628-B‑037-001-MY3 awarded to Y.-B C.), the National Health Research Institute (NHRI-EX103-10241BI), and in part from a grant from Chinese Medicine Research Center, China Medical University (the Ministry of Education, the Aim for the Top University Plan). This study was supported partially by Kaohsiung Medical University (Aim for the Top Universities Plan, grant No. KMU-TP105E32), the Ministry of Health and Welfare of Taiwan (MOHW106-TDU-B-212-144007), and the Health and Welfare surcharge of tobacco products. Publisher Copyright: {\textcopyright} 2017 Georg Thieme Verlag KG Stuttgart · New York.",
year = "2018",
month = jan,
day = "1",
doi = "10.1055/s-0043-113826",
language = "English",
volume = "84",
pages = "49--58",
journal = "Planta Medica",
issn = "0032-0943",
publisher = "Georg Thieme Verlag",
number = "1",
}
