Bioabsorbable fish scale for the internal fixation of fracture: A preliminary study

Cheng Hung Chou, Yong Guei Chen, Chien Chen Lin, Shang Ming Lin, Kai Chiang Yang, Shih Hsin Chang

研究成果: 雜誌貢獻文章同行評審

20 引文 斯高帕斯(Scopus)


Fish scales, which consist of type I collagen and hydroxyapatite (HA), were used to fabricate a bioabsorbable bone pin in this study. Fresh fish scales were decellularized and characterized to provide higher biocompatibility. The mechanical properties of fish scales were tested, and the microstructure of an acellular fish scale was examined. The growth curve of a myoblastic cell line (C2C12), which was cultured on the acellular fish scales, implied biocompatibility in vitro, and the morphology of the cells cultured on the scales was observed using scanning electron microscopy (SEM). A bone pin made of decellularized fish scales was used for the internal fixation of femur fractures in New Zealand rabbits. Periodic X-ray evaluations were obtained, and histologic examinations were performed postoperatively. The present results show good cell growth on decellularized fish scales, implying great biocompatibility in vitro. Using SEM, the cell morphology revealed great adhesion on a native, layered collagen structure. The Young's modulus was 332±50.4 MPa and the tensile strength was 34.4±6.9 MPa for the decellularized fish scales. Animal studies revealed that a fish-scale-derived bone pin improved the healing of bone fractures and degraded with time. After an 8-week implantation, the bone pin integrated with the adjacent tissue, and new extracellular matrix was synthesized around the implant. Our results proved that fish-scale-derived bone pins are a promising implant material for bone healing and clinical applications.
頁(從 - 到)2493-2502
期刊Tissue Engineering - Part A
出版狀態已發佈 - 9月 1 2014

ASJC Scopus subject areas

  • 生物工程
  • 生物化學
  • 生物醫學工程
  • 生物材料
  • 一般醫學


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