TY - JOUR
T1 - Beyond noise to function
T2 - reframing the global brain activity and its dynamic topography
AU - Zhang, Jianfeng
AU - Northoff, Georg
N1 - Funding Information:
This work is supported by Shenzhen-Hong Kong Institute of Brain Science—Shenzhen Fundamental Research Institutions (2022SHIBS0003), National Natural Science Foundation of China 32201129 and the Start-up Research Grant in Shenzhen University to J.Z., and the European Union’s Horizon 2020 Framework Programme for Research and Innovation under the Specific Grant Agreement No. 785907 (Human Brain Project SGA2), the grant from the Ministry of Science and Technology of China, National Key R&D Program of China (2016YFC1306700), the EJLB-Michael Smith Foundation, the Canada Institute of Health Research (CIHR), the Start-up Research Grant in Hangzhou Normal University, and the NFRF, uOBMRI Team grant to G.N.
Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - How global and local activity interact with each other is a common question in complex systems like climate and economy. Analogously, the brain too displays ‘global’ activity that interacts with local-regional activity and modulates behavior. The brain’s global activity, investigated as global signal in fMRI, so far, has mainly been conceived as non-neuronal noise. We here review the findings from healthy and clinical populations to demonstrate the neural basis and functions of global signal to brain and behavior. We show that global signal (i) is closely coupled with physiological signals and modulates the arousal level; and (ii) organizes an elaborated dynamic topography and coordinates the different forms of cognition. We also postulate a Dual-Layer Model including both background and surface layers. Together, the latest evidence strongly suggests the need to go beyond the view of global signal as noise by embracing a dual-layer model with background and surface layer.
AB - How global and local activity interact with each other is a common question in complex systems like climate and economy. Analogously, the brain too displays ‘global’ activity that interacts with local-regional activity and modulates behavior. The brain’s global activity, investigated as global signal in fMRI, so far, has mainly been conceived as non-neuronal noise. We here review the findings from healthy and clinical populations to demonstrate the neural basis and functions of global signal to brain and behavior. We show that global signal (i) is closely coupled with physiological signals and modulates the arousal level; and (ii) organizes an elaborated dynamic topography and coordinates the different forms of cognition. We also postulate a Dual-Layer Model including both background and surface layers. Together, the latest evidence strongly suggests the need to go beyond the view of global signal as noise by embracing a dual-layer model with background and surface layer.
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U2 - 10.1038/s42003-022-04297-6
DO - 10.1038/s42003-022-04297-6
M3 - Article
C2 - 36481785
AN - SCOPUS:85143559471
SN - 2399-3642
VL - 5
JO - Communications Biology
JF - Communications Biology
IS - 1
M1 - 1350
ER -