Bacteriological Efficacy of Nafcillin and Vancomycin Alone or Combined with Rifampicin or Amikacin in Experimental Meningitis Due to Methicillin-Susceptible or -Resistant Staphylococcus Aureus

Although meningitis due to Staphylococcus aureus is uncommon today in infants and children, it remains an important pathogen1), particularly in catheter-associated infections. In cerebrospinal fluid (CSF) shunt infections, S. aureus accounts for approximately one quarter of infections2,3) Optimal antimicrobial therapy of that infection and of other infections of the central nervous system due to S, aureus is problematic, particularly for disease due to methicillin (DMPPC)-resistant strains4, 5).