Bactericidal activity of soymilk fermentation broth by in vitro and animal models

Yi Ping Chin, Ko Chung Tsui, Mei Chieh Chen, Cheng Yi Wang, Chin Yuh Yang, Yuh Ling Lin

研究成果: 雜誌貢獻文章同行評審

15 引文 斯高帕斯(Scopus)


Soybean fermentation broth (SFB) exhibits potent antibacterial activity against different species of bacteria in in vitro assays and animal models. Four isoflavone compounds-daidzin, genistin, genistein, and daidzein-of SFB were analyzed and quantified by high-performance liquid chromatography. In the in vitro test, daidzin and daidzein had more potent antibacterial activity than genistin. The minimum inhibition concentration values for these bacteria of SFB ranged from 1.25% to 5%, and the minimum bactericidal concentration values of strains ranged from 2.5% to 10%, depending on the species or strain. Vancomycin-resistant Entercoccus faecalis (VRE) strains were also tested for susceptibility to SFB in two species of animal model: the Sprague-Dawley rat and the BALB/c mouse. SFB-fed Sprague-Dawley rats showed excellent elimination efficiency against VRE, close to 99% compared with the phosphate-buffered saline-fed control group. In the BALB/c mouse model, SFB antibacterial activity was 65-80% against VRE compared with the control. In conclusion, SFB contains natural antibacterial substances such as daidzin, genistin, and daidzein that inhibit bacterial growth.

頁(從 - 到)520-526
期刊Journal of Medicinal Food
出版狀態已發佈 - 6月 1 2012

ASJC Scopus subject areas

  • 醫藥(雜項)
  • 營養與營養學


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