TY - JOUR
T1 - Autism spectrum disorder model mice
T2 - Focus on copy number variation and epigenetics
AU - Nakai, Nobuhiro
AU - Otsuka, Susumu
AU - Myung, Jihwan
AU - Takumi, Toru
N1 - Publisher Copyright:
© 2015, The Author(s).
PY - 2015/10/1
Y1 - 2015/10/1
N2 - Autism spectrum disorder (ASD) is gathering concerns in socially developed countries. ASD is a neuropsychiatric disorder of genetic origin with high prevalence of 1%–2%. The patients with ASD characteristically show impaired social skills. Today, many genetic studies identify numerous susceptible genes and genetic loci associated with ASD. Although some genetic factors can lead to abnormal brain function linked to ASD phenotypes, the pathogenic mechanism of ASD is still unclear. Here, we discuss a new mouse model for ASD as an advanced tool to understand the mechanism of ASD.
AB - Autism spectrum disorder (ASD) is gathering concerns in socially developed countries. ASD is a neuropsychiatric disorder of genetic origin with high prevalence of 1%–2%. The patients with ASD characteristically show impaired social skills. Today, many genetic studies identify numerous susceptible genes and genetic loci associated with ASD. Although some genetic factors can lead to abnormal brain function linked to ASD phenotypes, the pathogenic mechanism of ASD is still unclear. Here, we discuss a new mouse model for ASD as an advanced tool to understand the mechanism of ASD.
KW - ASD model mouse
KW - copy number variations
KW - DNA methylation
KW - histone modification
UR - http://www.scopus.com/inward/record.url?scp=84945443946&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84945443946&partnerID=8YFLogxK
U2 - 10.1007/s11427-015-4891-7
DO - 10.1007/s11427-015-4891-7
M3 - Review article
C2 - 26335737
AN - SCOPUS:84945443946
SN - 1674-7305
VL - 58
SP - 976
EP - 984
JO - Science China Life Sciences
JF - Science China Life Sciences
IS - 10
ER -