@article{091aaf3e834f4b91bf34c7c6d5c34312,
title = "Associations of influenza vaccination with severity of immune-related adverse events in patients with advanced thoracic cancers on immune checkpoint inhibitors",
abstract = "Background Whether influenza vaccination (FV) is associated with the severity of immune-related adverse events (IRAEs) in patients with advanced thoracic cancer on immune checkpoint inhibitors (ICIs) is not fully understood. Methods Patients enrolled in this retrospective cohort study were identified from the Vanderbilt BioVU database and their medical records were reviewed. Patients with advanced thoracic cancer who received FV within 3 months prior to or during their ICI treatment period were enrolled in the FV-positive cohort and those who did not were enrolled in the FV-negative cohort. The primary objective was to detect whether FV is associated with decreased IRAE severity. The secondary objectives were to evaluate whether FV is associated with a decreased risk for grade 3–5 IRAEs and better survival times. Multivariable ordinal logistic regression was used for the primary analysis. Results A total of 142 and 105 patients were enrolled in the FV-positive and FV-negative cohorts, respectively. There was no statistically significant difference in patient demographics or cumulative incidences of IRAEs between the two cohorts. In the primary analysis, FV was inversely associated with the severity of IRAEs (OR 0.63; p=0.046). In the secondary analysis, FV was associated with a decreased risk for grade 3–5 IRAEs (OR 0.42; p=0.005). Multivariable Cox regression showed that FV was not associated with survival times. Conclusions Our study showed that FV does not increase toxicity for patients with advanced thoracic cancer on ICIs and is associated with a decreased risk for grade 3–5 IRAEs. No statistically significant survival differences were found between patients with and without FV.",
author = "Lin, {Emily Pei Ying} and Huang, {Li Ching} and Jennifer Whisenant and Sally York and Travis Osterman and Jennifer Lewis and Wade Iams and Emily Skotte and Amanda Cass and Hsu, {Chih Yuan} and Yu Shyr and Leora Horn",
note = "Funding Information: Conflict of interest: E.P-Y. Lin has received support for the present manuscript from the Ministry of Science and Technology Taiwan (MOST107-2314-B-002-231, MOST108-2314-B-030-014, MOST109-2314-B-038-150 and MOST108-2314-B-002-197-MY2) and National Health Research Institute Taiwan (NHRI-EX109-10937BC). T. Osterman has received grants or contracts from Microsoft, outside the submitted work; consulting fees from AstraZeneca, outside the submitted work; and has a collaboration with GE Healthcare. W. Iams has received grants or contracts from the National Cancer Institute Vanderbilt Clinical Oncology Research Career Development Award (VCORCDP) 2K12CA090625-17, American Society of Clinical Oncology/Conquer Cancer Foundation Young Investigator Award, and National Comprehensive Cancer Network Young Investigator Award, outside the submitted work; consulting fees from OncLive, Clinical Care Options, Chardan, Outcomes Insights, Cello Health and Curio Science, outside the submitted work; and participation on advisory boards for Genentech, Jazz Pharma, G1 Therapeutics and Mirati, outside the submitted work. A. Cass has received payment or honoraria for speakers{\textquoteright} bureaus from Jazz, outside the submitted work; and participation on an advisory board for Roche-Genentech and Novartis, outside the submitted work. Y. Shyr has received support for the present manuscript from the National Institutes of Health (P30CA068485, U24CA163056, U24CA213274, P50CA236733, P50CA098131 and U54CA163072). L. Horn reports grants or contracts from Xcovery and Bristol Myers Squibb, outside the submitted work; consulting fees from AstraZeneca, Xcovery and Amgen, outside the submitted work; and participation on an advisory board for Roche-Genentech, Bristol Myers Squibb, Merck, Incyte and Tesaro, outside the submitted work. She is an employee of AstraZeneca. The remaining authors have nothing to disclose. Funding Information: Support statement: This work was supported by the National Institutes of Health (P30CA068485, U24CA163056, U24CA213274, P50CA236733, P50CA098131 and U54CA163072), Ministry of Science and Technology Taiwan (MOST107-2314-B-002-231, MOST108-2314-B-030-014, MOST109-2314-B-038-150 and MOST108-2314-B-002-197-MY2), National Health Research Institute Taiwan (NHRI-EX109-10937BC), and Taipei Medical University and Hospital (DP5-111-21314-07, TMU110-AE1-B13 and 110TMU-TMUH-02-5). Funding information for this article has been deposited with the Crossref Funder Registry. Funding Information: Acknowledgements: The dataset(s) used for the analyses described were obtained from Vanderbilt University Medical Center{\textquoteright}s BioVU, which is supported by numerous sources: institutional funding, private agencies and federal grants. These include the National Institutes of Health-funded Shared Instrumentation Grant S10RR025141, and Clinical and Translational Science Awards grants UL1TR002243, UL1TR000445 and UL1RR024975. Publisher Copyright: {\textcopyright} The authors 2022.",
year = "2022",
month = oct,
day = "1",
doi = "10.1183/23120541.00684-2021",
language = "English",
volume = "8",
journal = "ERJ Open Research",
issn = "2312-0541",
publisher = "European Respiratory Society",
number = "4",
}
