摘要
原文 | 英語 |
---|---|
頁(從 - 到) | 4021-4026 |
頁數 | 6 |
期刊 | Anticancer Research |
卷 | 38 |
發行號 | 7 |
出版狀態 | 已發佈 - 2018 |
Keywords
- Genetic polymorphism
- Methylenetetrahydrofolate reductase
- Potentially malignant oral disorders
- Taiwan
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於: Anticancer Research, 卷 38, 編號 7, 2018, p. 4021-4026.
研究成果: 雜誌貢獻 › 文章 › 同行評審
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TY - JOUR
T1 - Associations between MTHFR polymorphisms and the risk of potentially malignant oral disorders
AU - Senghore, T.
AU - Li, Y.-F.
AU - Sung, F.-C.
AU - Tsai, M.-H.
AU - Hua, C.-H.
AU - Liu, C.-S.
AU - Hung, M.-F.
AU - Yeh, C.-C.
N1 - Export Date: 18 October 2018 CODEN: ANTRD 通訊地址: Yeh, C.-C.; School of Public Health, Taipei Medical University, 250 Wu-Hsing Street, Taiwan; 電子郵件: [email protected] 化學物質/CAS: 5,10 methylenetetrahydrofolate reductase (FADH2), 9028-69-7; methylenetetrahydrofolate reductase (NADPH2), 71822-25-8; Methylenetetrahydrofolate Reductase (NADPH2) 參考文獻: Gupta, B., Johnson, N.W., Kumar, N., Global epidemiology of head and neck cancers: A continuing challenge (2016) Oncology, 91 (1), pp. 13-23; Chiang, C.-J., Lo, W.-C., Yang, Y.-W., You, S.-L., Chen, C.-J., Lai, M.S., Incidence and survival of adult cancer patients in Taiwan, 2002-2012 (2016) J Formosan Med Assoc, 115 (12), p. 13; Yang, P.Y., Chen, Y.T., Wang, Y.H., Su, N.Y., Yu, H.C., Chang, Y.C., Malignant transformation of oral submucous fibrosis in Taiwan: A nationwide population-based retrospective cohort study (2017) J Oral Pathol Med, 46 (10), pp. 1040-1045; Lyu, M.Y., Guo, Y.S., Li, S., Yang, D., Hua, H., Hospital-based epidemiological and clinical characterisation of the malignant transformation of oral leukoplakia in a Chinese population (2017) Int Dent J, 67 (4), pp. 252-259; Paulino, Y.C., Hurwitz, E.L., Warnakulasuriya, S., Gatewood, R.R., Pierson, K.D., Tenorio, L.F., Novotny, R., Badowski, G., Screening for oral potentially malignant disorders among areca (betel) nut chewers in Guam and Saipan (2014) BMC Oral Health, 14, p. 151; Fenech, M., The role of folic acid and vitamin B12 in genomic stability of human cells (2001) Mutat Res, 475 (1-2), pp. 57-67; Miri-Moghaddam, E., Saravani, S., Garme, Y., Khosravi, A., Bazi, A., Motazedian, J., Methylenetetrahydrofolate reductase C677T and A1298C gene polymorphisms in oral squamous cell carcinoma in South-East Iran (2016) J Oral Pathol Med, 45 (2), pp. 96-100; Weisberg, I., Tran, P., Christensen, B., Sibani, S., Rozen, R., A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity (1998) Mol Genet Metab, 64 (3), pp. 169-172; Fenech, M., The role of folic acid and vitamin B12 in genomic stability of human cells (2001) Mutat Res, 475 (1-2), pp. 57-67; Frosst, P., Blom, H.J., Milos, R., Goyette, P., Sheppard, C.A., Matthews, R.G., Boers, G.J., Rozen, R., A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase (1995) Nat Genet, 10 (1), pp. 111-113; Van Der Put, N.M., Gabreels, F., Stevens, E.M., Smeitink, J.A., Trijbels, F.J., Eskes, T.K., Van Den Heuvel, L.P., Blom, H.J., A second common mutation in the methylenetetrahydrofolate reductase gene: An additional risk factor for neural-tube defects? (1998) Am J Hum Genet, 62 (5), pp. 1044-1051; Tsai, C.W., Hsu, C.F., Tsai, M.H., Tsou, Y.A., Hua, C.H., Chang, W.S., Lin, C.C., Bau, D.T., Methylenetetrahydrofolate reductase (MTHFR) genotype, smoking habit, metastasis and oral cancer in Taiwan (2011) Anticancer Res, 31 (6), pp. 2395-2399; Warnakulasuriya, S., Johnson, N.W., Van Der Waal, I., Nomenclature and classification of potentially malignant disorders of the oral mucosa (2007) J Oral Pathol Med, 36 (10), pp. 575-580; Lievers, K.J., Boers, G.H., Verhoef, P., Den Heijer, M., Kluijtmans, L.A., Van Der Put, N.M., Trijbels, F.J., Blom, H.J., A second common variant in the methylenetetrahydrofolate reductase (MTHFR) gene and its relationship to MTHFR enzyme activity, homocysteine, and cardiovascular disease risk (2001) J Mol Med, 79 (9), pp. 522-528; Guo, S., Jiang, X., Chen, X., Chen, L., Li, X., Jia, Y., The protective effect of methylenetetrahydrofolate reductase C677T polymorphism against prostate cancer risk: Evidence from 23 case-control studies (2015) Gene, 565 (1), pp. 90-95; Sohn, K.J., Croxford, R., Yates, Z., Lucock, M., Kim, Y.I., Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate (2004) J Natl Cancer Inst, 96 (2), pp. 134-144; Jia, J., Ma, Z., Wu, S., Positive association between MTHFR C677T polymorphism and oral cancer risk: A meta-analysis (2014) Tumour Biol, 35 (5), pp. 4943-4948; Barbosa, A., Dos Santos, M., De Podesta, J.R., Gouvea, S.A., Von Zeidler, S.V., Louro, I.D., De Cordeiro-Silva, M.F., Polymorphisms in methylenetetrahydrofolate reductase and cystathionine beta-synthase in oral cancer - A case-control study in southeastern Brazilians (2016) Braz J Otorhinolaryngol, 82 (5), pp. 558-566; Chen, Z., Karaplis, A.C., Ackerman, S.L., Pogribny, I.P., Melnyk, S., Lussier-Cacan, S., Chen, M.F., Rozen, R., Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition (2001) Hum Mol Genet, 10 (5), pp. 433-443; Liu, C.S., Tsai, C.W., Hsia, T.C., Wang, R.F., Liu, C.J., Hang, L.W., Chiang, S.Y., Bau, D.T., Interaction of methylenetetrahydrofolate reductase genotype and smoking habit in Taiwanese lung cancer patients (2009) Cancer Genomics Proteomics, 6 (6), pp. 325-329; Chen, J., Ma, J., Stampfer, M.J., Palomeque, C., Selhub, J., Hunter, D.J., Linkage disequilibrium between the 677C>T and 1298A>C polymorphisms in human methylenetetrahydrofolate reductase gene and their contributions to risk of colorectal cancer (2002) Pharmacogenetics, 12 (4), pp. 339-342; Yang, C.X., Matsuo, K., Ito, H., Shinoda, M., Hatooka, S., Hirose, K., Wakai, K., Tajima, K., Gene-environment interactions between alcohol drinking and the MTHFR C677T polymorphism impact on esophageal cancer risk: Results of a case-control study in Japan (2005) Carcinogenesis, 26 (7), pp. 1285-1290; Zhuo, X., Song, J., Li, D., Wu, Y., Zhou, Q., MTHFR C677T polymorphism interaction with heavy alcohol consumption increases head and neck carcinoma risk (2015) Sci Rep, 5, p. 10671; Nazki, F.H., Sameer, A.S., Ganaie, B.A., Folate: Metabolism, genes, polymorphisms and the associated diseases (2014) Gene, 533 (1), pp. 11-20
PY - 2018
Y1 - 2018
N2 - Aim: The study aimed to investigate the role of two polymorphisms of methylenetetrahydrofolate reductase (MTHFR), C677T and A1298C, in the risk of potentially malignant oral disorders (PMODs). Materials and Methods: Genotypes of the MTHFR C677T and A1298C polymorphisms were determined using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) for 224 PMOD cases and 485 age-matched controls. Results: The C677T T allele-carrying genotypes were significantly associated with a decreased risk of PMODs [odds ratio (OR)=0.62, 95% confidence interval (CI)=0.44-0.86]. Haplotype analysis also indicated that the 677T/1298A haplotype was associated with a decreased risk of PMODs (OR=0.56, 95%CI=0.40-0.80). No significant interaction was observed between MTHFR polymorphisms and lifestyle factors. Conclusion: Our findings suggest that the T-allele-carrying MTHFR C677T genotype or haplotype may reduce the risk of PMODs. However, these observations require further confirmation using larger samples. © 2018 International Institute of Anticancer Research. All rights reserved.
AB - Aim: The study aimed to investigate the role of two polymorphisms of methylenetetrahydrofolate reductase (MTHFR), C677T and A1298C, in the risk of potentially malignant oral disorders (PMODs). Materials and Methods: Genotypes of the MTHFR C677T and A1298C polymorphisms were determined using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) for 224 PMOD cases and 485 age-matched controls. Results: The C677T T allele-carrying genotypes were significantly associated with a decreased risk of PMODs [odds ratio (OR)=0.62, 95% confidence interval (CI)=0.44-0.86]. Haplotype analysis also indicated that the 677T/1298A haplotype was associated with a decreased risk of PMODs (OR=0.56, 95%CI=0.40-0.80). No significant interaction was observed between MTHFR polymorphisms and lifestyle factors. Conclusion: Our findings suggest that the T-allele-carrying MTHFR C677T genotype or haplotype may reduce the risk of PMODs. However, these observations require further confirmation using larger samples. © 2018 International Institute of Anticancer Research. All rights reserved.
KW - Genetic polymorphism
KW - Methylenetetrahydrofolate reductase
KW - Potentially malignant oral disorders
KW - Taiwan
KW - 5,10 methylenetetrahydrofolate reductase (FADH2)
KW - genomic DNA
KW - methylenetetrahydrofolate reductase (NADPH2)
KW - adult
KW - alcohol consumption
KW - allele
KW - Article
KW - carcinogenesis
KW - cigarette smoking
KW - comparative study
KW - controlled study
KW - genetic association
KW - genotype
KW - haplotype
KW - human
KW - lifestyle
KW - major clinical study
KW - male
KW - molecular pathology
KW - mouth carcinoma
KW - potentially malignant oral disorder
KW - priority journal
KW - procedures
KW - risk reduction
KW - single nucleotide polymorphism
KW - case control study
KW - genetic predisposition
KW - genetics
KW - middle aged
KW - mouth tumor
KW - polymerase chain reaction
KW - restriction fragment length polymorphism
KW - Adult
KW - Alleles
KW - Case-Control Studies
KW - Genetic Predisposition to Disease
KW - Genotype
KW - Haplotypes
KW - Humans
KW - Male
KW - Methylenetetrahydrofolate Reductase (NADPH2)
KW - Middle Aged
KW - Mouth Neoplasms
KW - Polymerase Chain Reaction
KW - Polymorphism, Restriction Fragment Length
KW - Polymorphism, Single Nucleotide
KW - Genetic polymorphism
KW - Methylenetetrahydrofolate reductase
KW - Potentially malignant oral disorders
KW - Taiwan
M3 - Article
SN - 0250-7005
VL - 38
SP - 4021
EP - 4026
JO - Anticancer Research
JF - Anticancer Research
IS - 7
ER -