Associations between levels of urinary oxidative stress of 8-OHdG and risk of atopic diseases in children

Pang Yen Chen, Chien Wei Chen, Yu Jang Su, Wen Han Chang, Wei Fong Kao, Chen Chang Yang, I. Jen Wang

研究成果: 雜誌貢獻文章同行評審

6 引文 斯高帕斯(Scopus)


The oxidative stress biomarker of urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG) was reported to be changed in patients with allergic diseases. Measurement of urinary oxidative products is noninvasive. However, correlations between the severity levels of atopic diseases and oxidative stress remain unclear. This study aimed to investigate the association among urinary 8-OHdG, atopic dermatitis (AD), and the phenotypes of atopic diseases in children. In a nested case-control study, participants of kindergarten children were enrolled from the Childhood Environment and Allergic Diseases Study (CEAS). Urinary analyses and urinary 8-OHdG were performed on samples from 200 children with AD as cases and 200 age-and sex-matched controls. Our study presents the following main findings: (1) The urinary 8-OHdG levels were significantly higher in cases than controls. Higher urinary 8-OHdG levels were associated with the risk of AD in a dose-response-manner; (2) Children’s AD history was associated with higher risks of asthma, allergic rhinitis, and night pruritus; (3) For children with AD, urinary 8-OHdG levels of >75th percentile were associated with higher risk of asthma, compared with the reference group of 0–25th percentiles. In summary, this study provides better understanding of the underlying mechanisms of AD and urinary 8-OHdG by analyzing a large-scale sample survey in Taiwan.
頁(從 - 到)1-12
期刊International journal of environmental research and public health
出版狀態已發佈 - 11月 1 2020

ASJC Scopus subject areas

  • 公共衛生、環境和職業健康
  • 健康、毒理學和誘變


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