@article{cf187c838b834c27a1a06cbd802245ef,
title = "Association of matrix Metalloproteinase-9 rs3918242 promoter genotypes with colorectal cancer risk",
abstract = "Background/Aim: Matrix metalloproteinase-9 (MMP-9) is responsible for modifying extracellular components and plays a crucial role in the metastatic behavior of cancer. This study aimed at examining the role of MMP-9 rs3918242 genotypes on colorectal cancer (CRC) risk. Materials and Methods: A total of 362 CRC patients and 362 healthy subjects in Taiwan, were examined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methodology. Results: The MMP-9 rs3918242 TT genotype carriers had a slightly increased risk of CRC compared to CC carriers (p=0.1642, OR=1.88, 95% CI=0.84-4.16). Patients of CT/TT genotypes were on significantly higher risk of metastasis (p=0.0027) than those of CC genotype. No obvious association was found between MMP-9 genotype and CRC risk among ever-smokers, non-smokers, non-alcohol drinkers or alcohol drinkers. No significant correlation was observed between MMP-9 genotypic distributions with age, gender, tumor size or location. Conclusion: MMP-9 rs3918242 genotypes may interact with BMI to serve as a predictor for higher CRC risk, and independently as a predictor for metastasis.",
keywords = "Case-control study, Colorectal cancer, Genotype, MMP-9, Polymorphism, Taiwan",
author = "Wu, {Ming Hsien} and Tzeng, {Huey En} and Wu, {Cheng Nan} and Yueh, {Te Cheng} and Peng, {Yen Chun} and Tsai, {Chun Hao} and Wang, {Yun Chi} and Ke, {Tao Wei} and Pei, {Jen Sheng} and Chang, {Wen Shin} and Tsai, {Chia Wen} and Bau, {Da Tian}",
note = "Funding Information: The Authors would like to thank the personnel of the Tissue-Bank of China Medical University Hospital for their excellent technical assistance including all, doctors, nurses and colleagues. The excellent technical expertise and efforts from Chris Tung, Yu-Chen Hsiau and Hsin-Ting Li are also appreciated. This study was supported mainly by the Taichung Armed Forces General Hospital (108A11) to Dr. Wu MH and partially by Taichung Veterans General Hospital (TCVGHCTUST1087702) to Dr. Peng YC and Wu CN. The statistician Cheng-Li Lin who was supported with a research grant from Taiwan Ministry of Health and Welfare Clinical Trial and Research Center of Excellence (MOHW108-TDU-B-212-133004) is highly appreciated. Funding Information: The Authors would like to thank the personnel of the Tissue-Bank of China Medical University Hospital for their excellent technical assistance including all, doctors, nurses and colleagues. The excellent technical expertise and efforts from Chris Tung, Yu-Chen Hsiau and Hsin-Ting Li are also appreciated. This study was supported mainly by the Taichung Armed Forces General Hospital (108A11) to Dr. Wu MH and partially by Taichung Veterans General Hospital (TCVGH-CTUST1087702) to Dr. Peng YC and Wu CN. The statistician Cheng-Li Lin who was supported with a research grant from Taiwan Ministry of Health and Welfare Clinical Trial and Research Center of Excellence (MOHW108-TDU-B-212-133004) is highly appreciated. Publisher Copyright: {\textcopyright} 2019 International Institute of Anticancer Research. All rights reserved.",
year = "2019",
month = jan,
day = "1",
doi = "10.21873/anticanres.13867",
language = "English",
volume = "39",
pages = "6523--6529",
journal = "Anticancer Research",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "12",
}
