Association of apolipoprotein E genotype and intronic polymorphism of the presenilin-1 gene with Alzheimer's disease in elderly Taiwan Chinese

Chaur Jong Hu; Shing Ming Sung; Hsing Cheng Liu; Jan Gowth Chang

doi:10.1016/S0022-510X(98)00052-5

Association of apolipoprotein E genotype and intronic polymorphism of the presenilin-1 gene with Alzheimer's disease in elderly Taiwan Chinese

Chaur Jong Hu, Shing Ming Sung, Hsing Cheng Liu, Jan Gowth Chang

研究成果: 雜誌貢獻 › 文章 › 同行評審

7 引文斯高帕斯（Scopus）

摘要

We studied the apoliprotein E (apo-E) allele frequencies and intronic polymorphism of the presenilin-1 (PS-1) gene in 55 patients with late-onset Alzheimer's disease (AD) and 93 age- and sex-matched controls. The apoE ε4 allele frequency was significantly higher in the AD group than in the control group (0.255 versus 0.070, P

原文	英語
頁（從 - 到）	158-161
頁數	4
期刊	Journal of the Neurological Sciences
卷	157
發行號	2
DOIs	https://doi.org/10.1016/S0022-510X(98)00052-5
出版狀態	已發佈 - 5月 7 1998
對外發佈	是

ASJC Scopus subject areas

老化
神經病學（臨床）
手術
神經科學 (全部)
發展神經科學
神經內科

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abstract = "We studied the apoliprotein E (apo-E) allele frequencies and intronic polymorphism of the presenilin-1 (PS-1) gene in 55 patients with late-onset Alzheimer's disease (AD) and 93 age- and sex-matched controls. The apoE ε4 allele frequency was significantly higher in the AD group than in the control group (0.255 versus 0.070, P",

keywords = "Alzheimer's disease, Apolipoprotein E, Chinese, Dementia, Genetics, Presenilin- 1",

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AU - Liu, Hsing Cheng

AU - Chang, Jan Gowth

PY - 1998/5/7

Y1 - 1998/5/7

N2 - We studied the apoliprotein E (apo-E) allele frequencies and intronic polymorphism of the presenilin-1 (PS-1) gene in 55 patients with late-onset Alzheimer's disease (AD) and 93 age- and sex-matched controls. The apoE ε4 allele frequency was significantly higher in the AD group than in the control group (0.255 versus 0.070, P

AB - We studied the apoliprotein E (apo-E) allele frequencies and intronic polymorphism of the presenilin-1 (PS-1) gene in 55 patients with late-onset Alzheimer's disease (AD) and 93 age- and sex-matched controls. The apoE ε4 allele frequency was significantly higher in the AD group than in the control group (0.255 versus 0.070, P

KW - Alzheimer's disease

KW - Apolipoprotein E

KW - Chinese

KW - Dementia

KW - Genetics

KW - Presenilin- 1

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Association of apolipoprotein E genotype and intronic polymorphism of the presenilin-1 gene with Alzheimer's disease in elderly Taiwan Chinese

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