TY - JOUR
T1 - Association between type 2 diabetes and risk of cancer mortality
T2 - a pooled analysis of over 771,000 individuals in the Asia Cohort Consortium
AU - Chen, Yu
AU - Wu, Fen
AU - Saito, Eiko
AU - Lin, Yingsong
AU - Song, Minkyo
AU - Luu, Hung N.
AU - Gupta, Prakash C.
AU - Sawada, Norie
AU - Tamakoshi, Akiko
AU - Shu, Xiao Ou
AU - Koh, Woon Puay
AU - Xiang, Yong Bing
AU - Tomata, Yasutake
AU - Sugiyama, Kemmyo
AU - Park, Sue K.
AU - Matsuo, Keitaro
AU - Nagata, Chisato
AU - Sugawara, Yumi
AU - Qiao, You Lin
AU - You, San Lin
AU - Wang, Renwei
AU - Shin, Myung Hee
AU - Pan, Wen Harn
AU - Pednekar, Mangesh S.
AU - Tsugane, Shoichiro
AU - Cai, Hui
AU - Yuan, Jian Min
AU - Gao, Yu Tang
AU - Tsuji, Ichiro
AU - Kanemura, Seiki
AU - Ito, Hidemi
AU - Wada, Keiko
AU - Ahn, Yoon Ok
AU - Yoo, Keun Young
AU - Ahsan, Habibul
AU - Chia, Kee Seng
AU - Boffetta, Paolo
AU - Zheng, Wei
AU - Inoue, Manami
AU - Kang, Daehee
AU - Potter, John D.
N1 - Publisher Copyright:
© 2017, Springer-Verlag Berlin Heidelberg.
PY - 2017/6/1
Y1 - 2017/6/1
N2 - Aims/hypothesis: The aims of the study were to evaluate the association between type 2 diabetes and the risk of death from any cancer and specific cancers in East and South Asians. Methods: Pooled analyses were conducted of 19 prospective population-based cohorts included in the Asia Cohort Consortium, comprising data from 658,611 East Asians and 112,686 South Asians. HRs were used to compare individuals with diabetes at baseline with those without diabetes for the risk of death from any cancer and from site-specific cancers, including cancers of the oesophagus, stomach, colorectum, colon, rectum, liver, bile duct, pancreas, lung, breast, endometrium, cervix, ovary, prostate, bladder, kidney and thyroid, as well as lymphoma and leukaemia. Results: During a mean follow-up of 12.7 years, 37,343 cancer deaths (36,667 in East Asians and 676 in South Asians) were identified. Baseline diabetes status was statistically significantly associated with an increased risk of death from any cancer (HR 1.26; 95% CI 1.21, 1.31). Significant positive associations with diabetes were observed for cancers of the colorectum (HR 1.41; 95% CI 1.26, 1.57), liver (HR 2.05; 95% CI 1.77, 2.38), bile duct (HR 1.41; 95% CI 1.04, 1.92), gallbladder (HR 1.33; 95% CI 1.10, 1.61), pancreas (HR 1.53; 95% CI 1.32, 1.77), breast (HR 1.72; 95% CI 1.34, 2.19), endometrium (HR 2.73; 95% CI 1.53, 4.85), ovary (HR 1.60; 95% CI 1.06, 2.42), prostate (HR 1.41; 95% CI 1.09, 1.82), kidney (HR 1.84; 95% CI 1.28, 2.64) and thyroid (HR 1.99; 95% CI 1.03, 3.86), as well as lymphoma (HR 1.39; 95% CI 1.04, 1.86). Diabetes was not statistically significantly associated with the risk of death from leukaemia and cancers of the bladder, cervix, oesophagus, stomach and lung. Conclusions/interpretation: Diabetes was associated with a 26% increased risk of death from any cancer in Asians. The pattern of associations with specific cancers suggests the need for better control (prevention, detection, management) of the growing epidemic of diabetes (as well as obesity), in order to reduce cancer mortality.
AB - Aims/hypothesis: The aims of the study were to evaluate the association between type 2 diabetes and the risk of death from any cancer and specific cancers in East and South Asians. Methods: Pooled analyses were conducted of 19 prospective population-based cohorts included in the Asia Cohort Consortium, comprising data from 658,611 East Asians and 112,686 South Asians. HRs were used to compare individuals with diabetes at baseline with those without diabetes for the risk of death from any cancer and from site-specific cancers, including cancers of the oesophagus, stomach, colorectum, colon, rectum, liver, bile duct, pancreas, lung, breast, endometrium, cervix, ovary, prostate, bladder, kidney and thyroid, as well as lymphoma and leukaemia. Results: During a mean follow-up of 12.7 years, 37,343 cancer deaths (36,667 in East Asians and 676 in South Asians) were identified. Baseline diabetes status was statistically significantly associated with an increased risk of death from any cancer (HR 1.26; 95% CI 1.21, 1.31). Significant positive associations with diabetes were observed for cancers of the colorectum (HR 1.41; 95% CI 1.26, 1.57), liver (HR 2.05; 95% CI 1.77, 2.38), bile duct (HR 1.41; 95% CI 1.04, 1.92), gallbladder (HR 1.33; 95% CI 1.10, 1.61), pancreas (HR 1.53; 95% CI 1.32, 1.77), breast (HR 1.72; 95% CI 1.34, 2.19), endometrium (HR 2.73; 95% CI 1.53, 4.85), ovary (HR 1.60; 95% CI 1.06, 2.42), prostate (HR 1.41; 95% CI 1.09, 1.82), kidney (HR 1.84; 95% CI 1.28, 2.64) and thyroid (HR 1.99; 95% CI 1.03, 3.86), as well as lymphoma (HR 1.39; 95% CI 1.04, 1.86). Diabetes was not statistically significantly associated with the risk of death from leukaemia and cancers of the bladder, cervix, oesophagus, stomach and lung. Conclusions/interpretation: Diabetes was associated with a 26% increased risk of death from any cancer in Asians. The pattern of associations with specific cancers suggests the need for better control (prevention, detection, management) of the growing epidemic of diabetes (as well as obesity), in order to reduce cancer mortality.
KW - Asia Cohort Consortium
KW - Asians
KW - Cancer mortality
KW - Meta-analysis
KW - Type 2 diabetes
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U2 - 10.1007/s00125-017-4229-z
DO - 10.1007/s00125-017-4229-z
M3 - Article
C2 - 28265721
AN - SCOPUS:85014523865
SN - 0012-186X
VL - 60
SP - 1022
EP - 1032
JO - Diabetologia
JF - Diabetologia
IS - 6
ER -
