Association between statin use and dry eye disease in patients with hyperlipidemia: A population-based retrospective cohort study

Yong Wei Wang, Sian De Liu, Guan Ling Lin, Evelyn Jou Chen Huang, Joseph Jordan Keller, Li Hsuan Wang

研究成果: 雜誌貢獻文章同行評審

摘要

Higher serum cholesterol levels have been associated with an increased risk of dry eye disease (DED). The relationship between statin (HMG-CoA reductase inhibitor) use and DED in patients with hyperlipidemia remains unclear. To investigate the association between statin use and the risk of DED in patients with hyperlipidemia, we conducted a population-based retrospective cohort study utilizing data from Taiwan's Longitudinal Generation Tracking Database. Patients were categorized into statin users and nonusers, with a 5-year follow-up period. The study identified patients with newly diagnosed hyperlipidemia, excluding those with prior DED diagnoses. Matching and adjustments for covariates resulted in 41,931 individuals in each group. Patients receiving statin therapy were compared with those unexposed. Cumulative exposure doses were also evaluated to assess dose–response relationships. The primary outcome was the incidence of DED diagnosed during the follow-up period. Cox proportional hazards regression models estimated the risk of DED, and conditional logistic regression analyzed the dose–response effect of statin exposure. Among 41,931 matched pairs, statin users exhibited a slightly increased risk of developing DED compared with nonusers (adjusted hazard ratio, 1.06; 95% CI, 1.02–1.11; p < 0.01). However, no dose–response relationship was observed between statin exposure and DED risk. Statin use among patients with hyperlipidemia is associated with a marginally higher risk of DED. These findings underscore the importance of regular eye examinations in this patient population to facilitate early detection and management of DED. © 2024 The Author(s). Clinical and Translational Science published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics.
原文英語
文章編號e70039
期刊Clinical and Translational Science
17
發行號10
DOIs
出版狀態已發佈 - 10月 2024

ASJC Scopus subject areas

  • 一般神經科學
  • 一般生物化學,遺傳學和分子生物學
  • 一般藥理學、毒理學和製藥學

指紋

深入研究「Association between statin use and dry eye disease in patients with hyperlipidemia: A population-based retrospective cohort study」主題。共同形成了獨特的指紋。

引用此