Association Between Statin Use and Bell’s Palsy: A Population-Based Study

Methods: This case-control study identified 1,977 subjects with Bell’s palsy as cases and 5,931 sex- and age-matched subjects without Bell’s palsy as controls from the Taiwan Longitudinal Health Insurance Database 2000. Conditional logistic regressions was used to estimate the odds ratio (OR) and 95 % confidence interval (CI) for previous use of statins between the cases and controls. The associations of regular and irregular statin users with Bell’s palsy were further analyzed. Background: Several reports mention that statin (HMG-CoA reductase inhibitor) use seems to be associated with several neurologic disorders and that the lipid-lowering effect of statins may contribute to some neural toxicity. Objective: This study aimed to evaluate the association between statin use and Bell’s palsy using a population-based health insurance database. Results: By Chi-square test, there was a significant difference in the prevalence of statin use between cases and controls (23.2 vs. 16.4 %, p < 0.001). Conditional logistic regression analysis revealed that after adjusting for diabetes mellitus, hypertension, and hyperlipidemia, the OR for prior statin use was 1.47 (95 % CI 1.28–1.69) for cases compared with controls. Bell’s palsy was significantly associated with previous regular statin use (≥60 days within 6 months) (adjusted OR: 1.46, 95 % CI 1.28–1.67). However, there was no increased adjusted OR of irregular statin use (<60 days within 6 months) for cases compared with controls (OR: 1.09, 95 % CI 0.82–1.46). Conclusions: Our present data suggest a potential association between regular statin use and Bell’s palsy.