摘要
Background: The purpose of this study was to assess the predictive factors of optic neuropathy among patients with nasopharyngeal carcinoma (NPC). Methods: The analysis included 16 297 patients with NPC and 65 187 controls. Each patient with NPC was randomly frequency-matched with 4 individuals without NPC by age, sex, and index year. Cox proportional hazard models were applied to measure the hazard ratios (HRs) and 95% confidence intervals (CIs) of optic neuropathy development associated with NPC. Results: The risk of optic neuropathy was significantly higher in the NPC cohort (adjusted HR [aHR] 3.42; 95% CI 2.85-4.09; P <.001). Independent risk factors for optic neuropathy among patients with NPC included stroke (aHR 1.7; 95% CI 1.07-2.7; P =.03) and receipt of chemotherapy (aHR 1.55; 95% CI 1.17-2.06; P =.002). Conclusion: The risk of optic neuropathy was significantly higher in patients with NPC than in the general population.
原文 | 英語 |
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頁(從 - 到) | 1977-1985 |
頁數 | 9 |
期刊 | Head and Neck |
卷 | 40 |
發行號 | 9 |
DOIs | |
出版狀態 | 已發佈 - 9月 2018 |
對外發佈 | 是 |
ASJC Scopus subject areas
- 耳鼻咽喉科