TY - JOUR
T1 - Association between hepatitis C virus infection and subsequent chronic inflammatory skin disease
AU - Ma, Sheng Hsiang
AU - Tai, Ying Hsuan
AU - Dai, Ying Xiu
AU - Chang, Yun Ting
AU - Chen, Tzeng Ji
AU - Chen, Mu Hong
N1 - Funding Information:
This study was funded by the Ministry of Science and Technology, Taiwan (grant MOST 107‐2314‐B‐075‐032‐MY3 and MOST 110‐2314‐B‐075‐056‐MY3).
Publisher Copyright:
© 2021 Japanese Dermatological Association
PY - 2021/12
Y1 - 2021/12
N2 - Hepatitis C virus (HCV) infection is associated with several cutaneous manifestations, including lichen planus and psoriasis. However, its association with other chronic inflammatory skin diseases (CISD) remains largely unknown. The aim of this study was to investigate the association between HCV infection and CISD. Participants were recruited from the National Health Insurance Research Database in Taiwan. Altogether 23 509 patients with HCV infection and 94 036 matched controls were included to assess the risk of CISD. A Cox regression model was used for the analyses. Compared with controls, patients with HCV infection had an adjusted hazard ratio (aHR) of 6.34 (95% confidence interval [CI], 5.30–7.58) for CISD after adjustment for potential confounders. Regarding individual CISD, patients with HCV infection had a significantly increased risk of developing lichen planus, psoriasis, vitiligo, alopecia areata, and cutaneous lupus erythematosus. Interferon-based antiviral therapy (IFN-based AVT) was significantly associated with a decreased risk of CISD (aHR = 0.42; 95% CI, 0.28–0.64). Patients with HCV infection had a significantly increased risk of CISD, while IFN-based AVT was associated with a decreased risk. These findings suggest monitoring of CISD in patients with HCV infection.
AB - Hepatitis C virus (HCV) infection is associated with several cutaneous manifestations, including lichen planus and psoriasis. However, its association with other chronic inflammatory skin diseases (CISD) remains largely unknown. The aim of this study was to investigate the association between HCV infection and CISD. Participants were recruited from the National Health Insurance Research Database in Taiwan. Altogether 23 509 patients with HCV infection and 94 036 matched controls were included to assess the risk of CISD. A Cox regression model was used for the analyses. Compared with controls, patients with HCV infection had an adjusted hazard ratio (aHR) of 6.34 (95% confidence interval [CI], 5.30–7.58) for CISD after adjustment for potential confounders. Regarding individual CISD, patients with HCV infection had a significantly increased risk of developing lichen planus, psoriasis, vitiligo, alopecia areata, and cutaneous lupus erythematosus. Interferon-based antiviral therapy (IFN-based AVT) was significantly associated with a decreased risk of CISD (aHR = 0.42; 95% CI, 0.28–0.64). Patients with HCV infection had a significantly increased risk of CISD, while IFN-based AVT was associated with a decreased risk. These findings suggest monitoring of CISD in patients with HCV infection.
KW - chronic inflammatory skin disease
KW - cohort study
KW - hepatitis C virus
KW - interferon-based antiviral therapy
KW - Taiwan’s National Health Insurance Research Database
UR - http://www.scopus.com/inward/record.url?scp=85113786540&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85113786540&partnerID=8YFLogxK
U2 - 10.1111/1346-8138.16129
DO - 10.1111/1346-8138.16129
M3 - Article
C2 - 34460962
AN - SCOPUS:85113786540
SN - 0385-2407
VL - 48
SP - 1884
EP - 1891
JO - Journal of Dermatology
JF - Journal of Dermatology
IS - 12
ER -
