TY - JOUR
T1 - Association between chronic hepatitis C virus infection and bone mineral density
AU - Lin, Jung-Chun
AU - Hsieh, Tsai-Yuan
AU - Wu, Chia-Chun
AU - Chen, Peng-Jen
AU - Chueh, Tung-Hung
AU - Chang, Wei-Kuo
AU - Chu, Heng-Cheng
N1 - 被引用次數：10
Export Date: 22 March 2016
CODEN: CTIND
通訊地址: Chu, H.-C.; Division of Gastroenterology, Tri-Service General Hospital, National Defense Medical Center, Cheng-Kung Road, Taipei, Taiwan; 電子郵件： [email protected]
參考文獻: Raisz, L.G., Clinical practice. 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PY - 2012
Y1 - 2012
N2 - Whether chronic hepatitis C virus (HCV) infection is a risk factor for the development of bone disease has long been controversial. For this reason, chronic HCV-infected participants (n = 69) were recruited into a prospective cohort study and underwent dual-energy X-ray absorptiometry for determination of bone mineral density (BMD). Fibrosis staging was evaluated according to the noninvasive index FIB-4. T scores at the femoral neck and lumbar spine were used as the primary outcome variables to assess the association between degree of liver disease and BMD. The study cohort was 41 % male with a mean age of 53.6 years. The mean BMD, Z score, and T score values of lumbar spine in chronic hepatitis C (CHC) patients were significantly lower than those in healthy controls (p
AB - Whether chronic hepatitis C virus (HCV) infection is a risk factor for the development of bone disease has long been controversial. For this reason, chronic HCV-infected participants (n = 69) were recruited into a prospective cohort study and underwent dual-energy X-ray absorptiometry for determination of bone mineral density (BMD). Fibrosis staging was evaluated according to the noninvasive index FIB-4. T scores at the femoral neck and lumbar spine were used as the primary outcome variables to assess the association between degree of liver disease and BMD. The study cohort was 41 % male with a mean age of 53.6 years. The mean BMD, Z score, and T score values of lumbar spine in chronic hepatitis C (CHC) patients were significantly lower than those in healthy controls (p
KW - Bone mineral density
KW - Osteodystrophy
KW - Osteoporosis
KW - Viral hepatitis
KW - alkaline phosphatase bone isoenzyme
KW - carboxy terminal telopeptide
KW - adult
KW - article
KW - body composition
KW - bone density
KW - disease association
KW - disease severity
KW - dual energy X ray absorptiometry
KW - female
KW - femur neck
KW - hepatitis C
KW - human
KW - liver fibrosis
KW - lumbar spine
KW - major clinical study
KW - male
KW - osteoporosis
KW - premenopause
KW - priority journal
KW - scoring system
KW - Absorptiometry, Photon
KW - Bone Density
KW - Bone Diseases, Metabolic
KW - Case-Control Studies
KW - Female
KW - Hepatitis C, Chronic
KW - Humans
KW - Liver Cirrhosis
KW - Male
KW - Middle Aged
KW - Premenopause
U2 - 10.1007/s00223-012-9653-y
DO - 10.1007/s00223-012-9653-y
M3 - Article
SN - 0171-967X
VL - 91
SP - 423
EP - 429
JO - Calcified Tissue International
JF - Calcified Tissue International
IS - 6
ER -
