TY - JOUR
T1 - Association Between Adhesive Capsulitis and Thyroid Disease: A Meta-Analysis
AU - Chuang, Shu-Han
AU - Chen, Yu-Pin
AU - Huang, Shu-Wei
AU - Kuo, Yi-Jie
PY - 2023
Y1 - 2023
N2 - Background Adhesive capsulitis (AC) is a common clinical condition of the shoulders without a clear pathophysiology or etiology. Although thyroid disease has been linked to AC, an appropriate understanding of the disease and its epidemiological evidence are lacking. This meta-analysis investigated the association of AC with thyroid disease and identified which manifestations of thyroid disease contribute to the risk of AC. Methods The databases of PubMed, Embase, and Scopus were searched for literature retrieval up to September 20, 2022. Articles evaluating the association between AC and any type of thyroid disease were enrolled. Data from studies reporting the prevalence and its 95% confidence interval (CI) were pooled. Subgroup analysis was performed on the different manifestations of thyroid disease. We explored heterogeneity with sensitivity analyses and publication bias with funnel plots and Egger's tests. Trim and fill analysis was conducted if publication bias was found. Results In total, 10 case–control studies comprising a total of 127,967 patients were included. The prevalence of thyroid disease was significantly higher in patients with AC (odds ratio [OR] = 1.87, 95% CI: 1.37–2.57, P < 0.0001) than in patients without AC. The results of subgroup analysis indicated significantly higher rates of hypothyroidism (OR = 1.92, 95% CI: 1.09–3.39, P = 0.02) and subclinical hypothyroidism (OR = 2.56, 95% CI: 1.81–3.63, P < 0.00001), but not hyperthyroidism (OR = 1.42, 95% CI: 0.63–3.22, P = 0.40), among patients with AC than among those without AC. Conclusions Our meta-analysis demonstrated that thyroid disease, especially when presenting as hypothyroidism or subclinical hypothyroidism, is associated with an increased risk of AC. Evidence for an association between hyperthyroidism and AC was not found, although this may be due to the lack of related studies. Further research on the pathogeneses of and relationship between these two diseases is warranted.
AB - Background Adhesive capsulitis (AC) is a common clinical condition of the shoulders without a clear pathophysiology or etiology. Although thyroid disease has been linked to AC, an appropriate understanding of the disease and its epidemiological evidence are lacking. This meta-analysis investigated the association of AC with thyroid disease and identified which manifestations of thyroid disease contribute to the risk of AC. Methods The databases of PubMed, Embase, and Scopus were searched for literature retrieval up to September 20, 2022. Articles evaluating the association between AC and any type of thyroid disease were enrolled. Data from studies reporting the prevalence and its 95% confidence interval (CI) were pooled. Subgroup analysis was performed on the different manifestations of thyroid disease. We explored heterogeneity with sensitivity analyses and publication bias with funnel plots and Egger's tests. Trim and fill analysis was conducted if publication bias was found. Results In total, 10 case–control studies comprising a total of 127,967 patients were included. The prevalence of thyroid disease was significantly higher in patients with AC (odds ratio [OR] = 1.87, 95% CI: 1.37–2.57, P < 0.0001) than in patients without AC. The results of subgroup analysis indicated significantly higher rates of hypothyroidism (OR = 1.92, 95% CI: 1.09–3.39, P = 0.02) and subclinical hypothyroidism (OR = 2.56, 95% CI: 1.81–3.63, P < 0.00001), but not hyperthyroidism (OR = 1.42, 95% CI: 0.63–3.22, P = 0.40), among patients with AC than among those without AC. Conclusions Our meta-analysis demonstrated that thyroid disease, especially when presenting as hypothyroidism or subclinical hypothyroidism, is associated with an increased risk of AC. Evidence for an association between hyperthyroidism and AC was not found, although this may be due to the lack of related studies. Further research on the pathogeneses of and relationship between these two diseases is warranted.
KW - Adhesive capsulitis
KW - thyroid disease
KW - hypothyroidism
KW - subclinical hypothyroidism
KW - hyperthyroidism
U2 - 10.1016/j.jse.2023.01.033
DO - 10.1016/j.jse.2023.01.033
M3 - Article
SN - 1058-2746
JO - Journal of Shoulder and Elbow Surgery
JF - Journal of Shoulder and Elbow Surgery
ER -