Associated bone mineral density and obstructive sleep apnea in chronic obstructive pulmonary disease

Tsai Yu Wang, Yu Lun Lo, Pai Chien Chou, Fu Tsai Chung, Shu Min Lin, Ting Yu Lin, Horng Chyuan Lin, Chun Hua Wang, Chih Teng Yu, Han Pin Kuo

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17 引文 斯高帕斯(Scopus)


Background: Osteoporosis is an important issue for patients with chronic obstructive pulmonary disease (COPD). Worse systemic infammation and reduced exercise capacity have been reported in COPD patients with obstructive sleep apnea (OSA), implying that OSA may be an independent factor for osteoporosis in COPD patients. Methods: A total of 66 patients with bone mineral density (BMD) and polysomnography results from a previous COPD cohort (January 2008 to January 2013) were retrospectively enrolled. Clinical characteristics such as medication, pulmonary function, BMD, and results of polysomnography were analyzed. Results: The BMD in those with OSA was significantly lower than in those without OSA (-1.99±1.63 versus -1.27±1.14, P=0.045). In univariate analysis, body mass index, forced expiratory volume in 1 second, percentage of predicted value, incremental shuttle walk test, apnea-hypopnea index, and oxygen desaturation index (ODI) were signifcantly associated with BMD. After multivariate linear regression analysis, the ODI was still an independent factor for BMD. In addition, smaller total lung capacity is significantly associated with higher ODI and lower BMD, which implies that lower BMD might cause severer OSA via decreased total lung capacity. Conclusion: OSA may be an independent factor for BMD in patients with COPD, which implies a possible vicious cycle takes place in these patients.
頁(從 - 到)231-237
期刊International Journal of COPD
出版狀態已發佈 - 1月 29 2015

ASJC Scopus subject areas

  • 肺和呼吸系統醫學
  • 健康政策
  • 公共衛生、環境和職業健康


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