Assisted therapy with platelet-rich plasma for burn patients: A meta-analysis and systematic review

Yu Chien Kao, Dai Zhu Lin, Sheng Lian Lee, Chiehfeng Chen, Hsian Jenn Wang, Wen Kuan Chiu

研究成果: 雜誌貢獻文章同行評審

3 引文 斯高帕斯(Scopus)


Introduction: Platelet-rich plasma (PRP) therapy has been used in different medical fields, but its effectiveness in burn wound healing remains debatable. In this study, we performed a systematic review and meta-analysis of the available evidence on burn patients treated with PRP to evaluate the safety and efficacy of the treatment. Methods: Randomized controlled trials evaluating the efficacy of PRP in patients with burn injuries were selected. Eligible retrospective studies were abstracted and assessed for the risk of bias by two reviewers and results of mean time to complete epithelization and wound closure rate in the included studies were analyzed. Studies on the correlation between PRP and burn wound healing published in English or Chinese before March 2020 were retrieved from PubMed. Results: Eight studies (including 449 patients) met our inclusion criteria. Qualitative analysis revealed that compared with the control group, the PRP group had significantly better wound closure rates at weeks 2 (mean difference (MD): 12.79 [95% confidence interval (CI): 7.08, 18.49]; I2: 0%; p < 0.0001) and 3 (MD: 12.66 [95% CI: 5.97, 19.34]; I2: 55%; p = 0.0002) and time to complete epithelialization (MD: −3.45 [95% CI: −4.87, −2.04] (days); I2: 0%; p < 0.00001). There was no significant difference in infection rate or graft take rate. Conclusions: PRP application can accelerate wound closure, however, it has no effect on the rates of wound infection and graft take rate.
頁(從 - 到)1012-1023
出版狀態已發佈 - 8月 2021

ASJC Scopus subject areas

  • 手術
  • 急診醫學
  • 重症監護和重症監護醫學


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