TY - CHAP
T1 - Areca nut may kill cells in a different way
AU - Lin, Mei Huei
AU - Liu, Shyun Yeu
AU - Liu, Young Chau
PY - 2011
Y1 - 2011
N2 - Areca nut (AN, Areca catechu L.) is a popular but carcinogenic chewing material used by approximately 200-600 million people worldwide. In the past few decades, AN has been discovered to possess genotoxic, cytostatic, and cytotoxic effects on cells. Some ingredients of AN, such as AN extract (ANE), arecoline, hydroxychavicol, and oligomeric procyanidins were demonstrated to stimulate apoptotic and/or growth arresting phenotypes in treated cells. However, our recent studies showed that ANE predominantly induces the autophagic responses, albeit the simultaneous initiation of apoptotic pathway. This finding may renew the knowledge about the cytotoxic effects of AN on oral cells in physiological conditions.
AB - Areca nut (AN, Areca catechu L.) is a popular but carcinogenic chewing material used by approximately 200-600 million people worldwide. In the past few decades, AN has been discovered to possess genotoxic, cytostatic, and cytotoxic effects on cells. Some ingredients of AN, such as AN extract (ANE), arecoline, hydroxychavicol, and oligomeric procyanidins were demonstrated to stimulate apoptotic and/or growth arresting phenotypes in treated cells. However, our recent studies showed that ANE predominantly induces the autophagic responses, albeit the simultaneous initiation of apoptotic pathway. This finding may renew the knowledge about the cytotoxic effects of AN on oral cells in physiological conditions.
UR - http://www.scopus.com/inward/record.url?scp=84895344321&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84895344321&partnerID=8YFLogxK
M3 - Chapter
AN - SCOPUS:84895344321
SN - 9781617619786
SP - 167
EP - 172
BT - Nuts: Properties, Consumption and Nutrition
PB - Nova Science Publishers Inc
ER -