The nursing education system learning training is focus on improving technical skills. Most students directly into the workplace after graduation. For this reason, they are more interested in technical courses than basic courses. Students' learning effective reflect teachers' teaching quality and learning effective. In this research, the researcher will using the Zuvio cloud digital platform to expand the learning environment and evaluation methods. The sample of this study is all of two-year technical program student, they are less interested in the biostatistics of this research course. Researcher will through different design in teaching methods, in mid-term and final-term courses. Compare with difference teaching methods of learning effective, to showing which is better. Researchers will collect data in the biostatistics course, all students enrolled in research, not only compare teaching methods, but also through data to analysis framework about the student cost the time how to influence on the final exam results.