摘要
A variety of functionalities were introduced at 2-aroylquinoline's C5 position, which is considered equivalent to C-3′ of the B-ring of CA4, via Suzuki arylation, Sonogashira ethynylation, and Rosenmund-von Braun cyanation. These substitutions are rarely utilized in the modification of 3′-OH of CA4. The resulting products 6 and 7 having cyano and ethynyl groups exhibited comparable antiproliferative and tubulin inhibitory activities to colchicine.
原文 | 英語 |
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頁(從 - 到) | 9593-9600 |
頁數 | 8 |
期刊 | Organic and Biomolecular Chemistry |
卷 | 10 |
發行號 | 48 |
DOIs | |
出版狀態 | 已發佈 - 2012 |
ASJC Scopus subject areas
- 生物化學
- 物理與理論化學
- 有機化學