Application of stereotactic ablative radiotherapy in hepatocellular carcinoma patients with child-turcotte-pugh class B liver function

Cheng Hsiang Lo, Wen Yen Huang, Wei Chou Chang, Hsing Lung Chao, Kuen Tze Lin, Jen Fu Yang, Yi Chiao Cheng, Chun Shu Lin

研究成果: 雜誌貢獻文章同行評審

摘要

Background: The aim of this study is to evaluate the outcomes and prognostic factors in patients with hepatocellular carcinoma (HCC) and Child-Turcotte-Pugh (CTP) class B liver function after stereotactic ablative radiotherapy (SABR). Materials and Methods: This retrospective study evaluated patients with HCC and impaired liver function who underwent SABR between December 2007 and August 2016. All patients had CTP class B liver function before treatment. Local control (LC) rate, overall survival (OS) rate, prognostic factors, and radiation-related toxicity were evaluated. Results: This study included 34 patients. The majority had a CTP score of B7 (52.9%) and advanced HCC (91.2%). The median survival time was 4.8 months, and the 1-year OS rate was 21.4%. Only the tumor number (multiple vs. single) was identified as an independent predictor of survival. The 1-year LC rate was 95.8%. Eight patients (23.5%) developed the radiation-induced liver disease, and 15 (44.1%) had a CTP score decline of ≥2 within 3 months. Other toxicities were generally tolerable. Conclusion: SABR may be considered as an alternative option for patients with HCC and CTP class B liver function, particularly for those with a single lesion.
原文英語
頁(從 - 到)204-210
頁數7
期刊Journal of Medical Sciences (Taiwan)
38
發行號5
DOIs
出版狀態已發佈 - 2018
對外發佈

ASJC Scopus subject areas

  • 一般醫學

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