Background: Although the appendix may not be considered vital, recent studies have noted adverse health consequences after appendectomy. This study aimed to use a population-based data set to explore whether appendectomy increases the risk for subsequent ischemic heart disease (IHD) in a 3-y follow-up period. Materials and methods: This study used data from the Longitudinal Health Insurance Database 2000 in Taiwan. The study cohort included 5413 patients who underwent appendectomies. The comparison cohort was selected by randomly recruiting 16,239 enrollees matched with the study group in terms of sex, age, hypertension, hyperlipidemia, and diabetes. Each individual was tracked for 3y to identify whether he and/or she developed IHD during the follow-up period. Cox proportional hazard regressions were performed for analysis. Results: During a 3-y follow-up, 196 (3.62%) and 375 (2.31%) IHD incidents developed in the study and the comparison cohorts, respectively. For adults aged ≥18y, experiencing an appendectomy was independently associated with a 1.54-fold increased risk of IHD during the 3y of follow-up (95% CI = 1.29-1.84). The association persisted in further analyses stratified by age. Conclusions: There is an increased risk of subsequent IHD within 3y after appendectomy, and this underscores the need for more serious clinical decision-making in removing the appendix. Regular monitoring for IHDs is also recommended for patients who have undergone an appendectomy.
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