Apelin Promotes Prostate Cancer Metastasis by Downregulating TIMP2 via Increases in miR-106a-5p Expression

Tien Huang Lin, Sunny Li Yun Chang, Pham Minh Khanh, Nguyen Thi Nha Trang, Shan Chi Liu, Hsiao Chi Tsai, An Chen Chang, Jo Yu Lin, Po Chun Chen, Ju Fang Liu, Jeng Hung Guo, Chun Lin Liu, Hsi Chin Wu, Chih Hsin Tang

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1 引文 斯高帕斯(Scopus)

摘要

Prostate cancer commonly affects the urinary tract of men and metastatic prostate cancer has a very low survival rate. Apelin belongs to the family of adipokines and is associated with cancer development and metastasis. However, the effects of apelin in prostate cancer metastasis is undetermined. Analysis of the database revealed a positive correlation between apelin level with the progression and metastasis of prostate cancer patients. Apelin treatment facilitates cell migration and invasion through inhibiting tissue inhibitor of metalloproteinase 2 (TIMP2) expression. The increasing miR-106a-5p synthesis via c-Src/PI3K/Akt signaling pathway is controlled in apelin-regulated TIMP2 production and cell motility. Importantly, apelin blockade inhibits prostate cancer metastasis in the orthotopic mouse model. Thus, apelin is a promising therapeutic target for curing metastatic prostate cancer.
原文英語
文章編號3285
期刊Cells
11
發行號20
DOIs
出版狀態已發佈 - 10月 2022

ASJC Scopus subject areas

  • 生物化學、遺傳與分子生物學 (全部)

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