Apelin Promotes Prostate Cancer Metastasis by Downregulating TIMP2 via Increases in miR-106a-5p Expression

Tien Huang Lin; Sunny Li Yun Chang; Pham Minh Khanh; Nguyen Thi Nha Trang; Shan Chi Liu; Hsiao Chi Tsai; An Chen Chang; Jo Yu Lin; Po Chun Chen; Ju Fang Liu; Jeng Hung Guo; Chun Lin Liu; Hsi Chin Wu; Chih Hsin Tang

doi:10.3390/cells11203285

Apelin Promotes Prostate Cancer Metastasis by Downregulating TIMP2 via Increases in miR-106a-5p Expression

Tien Huang Lin, Sunny Li Yun Chang, Pham Minh Khanh, Nguyen Thi Nha Trang, Shan Chi Liu, Hsiao Chi Tsai, An Chen Chang, Jo Yu Lin, Po Chun Chen, Ju Fang Liu, Jeng Hung Guo, Chun Lin Liu, Hsi Chin Wu, Chih Hsin Tang

口腔衛生學系

研究成果: 雜誌貢獻 › 文章 › 同行評審

1 引文斯高帕斯（Scopus）

摘要

Prostate cancer commonly affects the urinary tract of men and metastatic prostate cancer has a very low survival rate. Apelin belongs to the family of adipokines and is associated with cancer development and metastasis. However, the effects of apelin in prostate cancer metastasis is undetermined. Analysis of the database revealed a positive correlation between apelin level with the progression and metastasis of prostate cancer patients. Apelin treatment facilitates cell migration and invasion through inhibiting tissue inhibitor of metalloproteinase 2 (TIMP2) expression. The increasing miR-106a-5p synthesis via c-Src/PI3K/Akt signaling pathway is controlled in apelin-regulated TIMP2 production and cell motility. Importantly, apelin blockade inhibits prostate cancer metastasis in the orthotopic mouse model. Thus, apelin is a promising therapeutic target for curing metastatic prostate cancer.

原文	英語
文章編號	3285
期刊	Cells
卷	11
發行號	20
DOIs	https://doi.org/10.3390/cells11203285
出版狀態	已發佈 - 10月 2022

ASJC Scopus subject areas

生物化學、遺傳與分子生物學 (全部)

UN SDG

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10.3390/cells11203285

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引用此

@article{c478405da85348bfb315d2fc4bc2acf7,

title = "Apelin Promotes Prostate Cancer Metastasis by Downregulating TIMP2 via Increases in miR-106a-5p Expression",

abstract = "Prostate cancer commonly affects the urinary tract of men and metastatic prostate cancer has a very low survival rate. Apelin belongs to the family of adipokines and is associated with cancer development and metastasis. However, the effects of apelin in prostate cancer metastasis is undetermined. Analysis of the database revealed a positive correlation between apelin level with the progression and metastasis of prostate cancer patients. Apelin treatment facilitates cell migration and invasion through inhibiting tissue inhibitor of metalloproteinase 2 (TIMP2) expression. The increasing miR-106a-5p synthesis via c-Src/PI3K/Akt signaling pathway is controlled in apelin-regulated TIMP2 production and cell motility. Importantly, apelin blockade inhibits prostate cancer metastasis in the orthotopic mouse model. Thus, apelin is a promising therapeutic target for curing metastatic prostate cancer.",

keywords = "apelin, metastasis, miR-106-5p, prostate cancer, TIMP2",

author = "Lin, {Tien Huang} and Chang, {Sunny Li Yun} and Khanh, {Pham Minh} and Trang, {Nguyen Thi Nha} and Liu, {Shan Chi} and Tsai, {Hsiao Chi} and Chang, {An Chen} and Lin, {Jo Yu} and Chen, {Po Chun} and Liu, {Ju Fang} and Guo, {Jeng Hung} and Liu, {Chun Lin} and Wu, {Hsi Chin} and Tang, {Chih Hsin}",

note = "Funding Information: This work was supported by the Ministry of Science and Technology, Taiwan (MOST 110-2314-B-039-012, 111-2314-B-039-051, and 110-2341-B-341-001-MY2), China Medical University Beigang Hospital (CMUBHR 108-012, 110CMURBHR-07, and CMUBHR109-007), and China Medical University hospital (DMR-110-091; DMR-111-095; DMR-111-099). Publisher Copyright: {\textcopyright} 2022 by the authors.",

year = "2022",

month = oct,

doi = "10.3390/cells11203285",

language = "English",

volume = "11",

journal = "Cells",

issn = "2073-4409",

number = "20",

}

TY - JOUR

T1 - Apelin Promotes Prostate Cancer Metastasis by Downregulating TIMP2 via Increases in miR-106a-5p Expression

AU - Lin, Tien Huang

AU - Chang, Sunny Li Yun

AU - Khanh, Pham Minh

AU - Trang, Nguyen Thi Nha

AU - Liu, Shan Chi

AU - Tsai, Hsiao Chi

AU - Chang, An Chen

AU - Lin, Jo Yu

AU - Chen, Po Chun

AU - Liu, Ju Fang

AU - Guo, Jeng Hung

AU - Liu, Chun Lin

AU - Wu, Hsi Chin

AU - Tang, Chih Hsin

N1 - Funding Information: This work was supported by the Ministry of Science and Technology, Taiwan (MOST 110-2314-B-039-012, 111-2314-B-039-051, and 110-2341-B-341-001-MY2), China Medical University Beigang Hospital (CMUBHR 108-012, 110CMURBHR-07, and CMUBHR109-007), and China Medical University hospital (DMR-110-091; DMR-111-095; DMR-111-099). Publisher Copyright: © 2022 by the authors.

PY - 2022/10

Y1 - 2022/10

N2 - Prostate cancer commonly affects the urinary tract of men and metastatic prostate cancer has a very low survival rate. Apelin belongs to the family of adipokines and is associated with cancer development and metastasis. However, the effects of apelin in prostate cancer metastasis is undetermined. Analysis of the database revealed a positive correlation between apelin level with the progression and metastasis of prostate cancer patients. Apelin treatment facilitates cell migration and invasion through inhibiting tissue inhibitor of metalloproteinase 2 (TIMP2) expression. The increasing miR-106a-5p synthesis via c-Src/PI3K/Akt signaling pathway is controlled in apelin-regulated TIMP2 production and cell motility. Importantly, apelin blockade inhibits prostate cancer metastasis in the orthotopic mouse model. Thus, apelin is a promising therapeutic target for curing metastatic prostate cancer.

AB - Prostate cancer commonly affects the urinary tract of men and metastatic prostate cancer has a very low survival rate. Apelin belongs to the family of adipokines and is associated with cancer development and metastasis. However, the effects of apelin in prostate cancer metastasis is undetermined. Analysis of the database revealed a positive correlation between apelin level with the progression and metastasis of prostate cancer patients. Apelin treatment facilitates cell migration and invasion through inhibiting tissue inhibitor of metalloproteinase 2 (TIMP2) expression. The increasing miR-106a-5p synthesis via c-Src/PI3K/Akt signaling pathway is controlled in apelin-regulated TIMP2 production and cell motility. Importantly, apelin blockade inhibits prostate cancer metastasis in the orthotopic mouse model. Thus, apelin is a promising therapeutic target for curing metastatic prostate cancer.

KW - apelin

KW - metastasis

KW - miR-106-5p

KW - prostate cancer

KW - TIMP2

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Apelin Promotes Prostate Cancer Metastasis by Downregulating TIMP2 via Increases in miR-106a-5p Expression

摘要

ASJC Scopus subject areas

UN SDG

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