APCcdh1 Activity in Mouse Oocytes Prevents Entry into the First Meiotic Division

Alexandra Reis; Heng Yu Chang; Mark Levasseur; Keith T. Jones

doi:10.1038/ncb1406

APC^cdh1 Activity in Mouse Oocytes Prevents Entry into the First Meiotic Division

Alexandra Reis, Heng Yu Chang, Mark Levasseur, Keith T. Jones

研究成果: 雜誌貢獻 › 文章 › 同行評審

134 引文斯高帕斯（Scopus）

摘要

Fully grown mammalian oocytes maintain a prophase I germinal-vesicle stage arrest in the ovary for extended periods before a luteinizing hormone surge induces entry into the first meiotic division. Cdh1 is an activator of the anaphase-promoting complex (APC) and APC^cdh1 is normally restricted to late M to early G1 phases of the cell cycle. Here, we find that APC^cdh1 is active in mouse oocytes and is necessary to maintain prophase arrest.

原文	英語
頁（從 - 到）	539-540
頁數	2
期刊	Nature Cell Biology
卷	8
發行號	5
DOIs	https://doi.org/10.1038/ncb1406
出版狀態	已發佈 - 5月 2006
對外發佈	是

ASJC Scopus subject areas

細胞生物學

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10.1038/ncb1406

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author = "Alexandra Reis and Chang, {Heng Yu} and Mark Levasseur and Jones, {Keith T.}",

note = "Funding Information: The Wellcome Trust supported this work with a project grant (075744) and equipment grant (065354) to K.T.J. We thank M. Aitchison for the preparation of figures.",

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APCcdh1 Activity in Mouse Oocytes Prevents Entry into the First Meiotic Division

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APC^cdh1 Activity in Mouse Oocytes Prevents Entry into the First Meiotic Division