TY - JOUR
T1 - Antitumor agents. Part 3
T2 - Synthesis and cytotoxicity of new trans-stilbene benzenesulfonamide derivatives
AU - Yang, Li Ming
AU - Lin, Shwu Jiuan
AU - Hsu, Fen Lin
AU - Yang, Tsang Hsiung
PY - 2002/4/8
Y1 - 2002/4/8
N2 - A new series of trans-stilbene benzenesulfonamide derivatives were designed and synthesized as potential antitumor agents. These new compounds were evaluated in the National Cancer Institute's 60 human tumor cell line in vitro screen. Compounds 9-13 were cytotoxic against several cell lines. Notably, two compounds, 9 and 12, demonstrated selective cytotoxic activity against BT-549 breast cancer (GI50=0.205 μM) and HT-29 colon cancer (GI50=0.554 μM), respectively.
AB - A new series of trans-stilbene benzenesulfonamide derivatives were designed and synthesized as potential antitumor agents. These new compounds were evaluated in the National Cancer Institute's 60 human tumor cell line in vitro screen. Compounds 9-13 were cytotoxic against several cell lines. Notably, two compounds, 9 and 12, demonstrated selective cytotoxic activity against BT-549 breast cancer (GI50=0.205 μM) and HT-29 colon cancer (GI50=0.554 μM), respectively.
UR - http://www.scopus.com/inward/record.url?scp=0037041264&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037041264&partnerID=8YFLogxK
U2 - 10.1016/S0960-894X(02)00092-6
DO - 10.1016/S0960-894X(02)00092-6
M3 - Article
C2 - 11909706
AN - SCOPUS:0037041264
SN - 0960-894X
VL - 12
SP - 1013
EP - 1015
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 7
ER -
