摘要
原文 | 英語 |
---|---|
期刊 | Experimental Diabetes Research |
卷 | 2012 |
DOIs | |
出版狀態 | 已發佈 - 2012 |
對外發佈 | 是 |
指紋
深入研究「Antioxidant sol-gel improves cutaneous wound healing in streptozotocin-induced diabetic rats」主題。共同形成了獨特的指紋。引用此
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於: Experimental Diabetes Research, 卷 2012, 2012.
研究成果: 雜誌貢獻 › 文章 › 同行評審
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TY - JOUR
T1 - Antioxidant sol-gel improves cutaneous wound healing in streptozotocin-induced diabetic rats
AU - Lee, Yen-Hsien
AU - Chang, Jung-Jhih
AU - Chien, Chiang-Ting
AU - Yang, Ming-Chien
AU - Chien, Hsiung-Fei
N1 - 被引用次數:10 Export Date: 16 March 2016 通訊地址: Yang, M.-C.; Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, Taipei 106, Taiwan; 電子郵件: [email protected] 化學物質/CAS: ascorbic acid, 134-03-2, 15421-15-5, 50-81-7; collagen, 9007-34-5; poloxamer, 9003-11-6; sodium chloride, 7647-14-5; hydroxyproline, 51-35-4, 6912-67-0; streptozocin, 18883-66-4; Antioxidants; Ascorbic Acid, 50-81-7; Hydroxyproline, 51-35-4; Poloxamer, 106392-12-5; Reactive Oxygen Species; Streptozocin, 18883-66-4 製造商: Sigma Aldrich, United States 參考文獻: Singer, A.J., Clark, R.A.F., Cutaneous wound healing (1999) New England Journal of Medicine, 341 (10), pp. 738-746. , DOI 10.1056/NEJM199909023411006; Luo, J.-D., Wang, Y.-Y., Fu, W.-L., Wu, J., Chen, A.F., Gene therapy of endothelial nitric oxide synthase and manganese superoxide dismutase restores delayed wound healing in type 1 diabetic mice (2004) Circulation, 110 (16), pp. 2484-2493. , DOI 10.1161/01.CIR.0000137969.87365.05; Schorah, C.J., Downing, C., Piripitsi, A., Gallivan, L., Al-Hazaa, A.H., Sanderson, M.J., Bodenham, A., Total vitamin C, ascorbic acid, and dehydroascorbic acid concentrations in plasma of critically ill patients (1996) American Journal of Clinical Nutrition, 63 (5), pp. 760-765; Clark, R.A.F., Oxidative stress and senescent fibroblasts in non-healing wounds as potential therapeutic targets (2008) Journal of Investigative Dermatology, 128 (10), pp. 2361-2364. , 2-s2.0-51749092207 10.1038/jid.2008.257; Schneir, M., Ramamurthy, N., Golub, L., Dietary ascorbic acid normalizes diabetes-induced underhydroxylation of nascent type I collagen molecules (1985) Collagen and Related Research, 5 (5), pp. 415-422; Briganti, S., Picardo, M., Antioxidant activity, lipid peroxidation and skin diseases. 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Yates, C.C., Whaley, D., Babu, R., Zhang, J., Krishna, P., Beckman, E., Pasculle, A.W., Wells, A., The effect of multifunctional polymer-based gels on wound healing in full thickness bacteria-contaminated mouse skin wound models (2007) Biomaterials, 28 (27), pp. 3977-3986. , DOI 10.1016/j.biomaterials.2007.05.008, PII S0142961207004048; Nemes, Z., Steinert, P.M., Bricks and mortar of the epidermal barrier (1999) Experimental and Molecular Medicine, 31 (1), pp. 5-19; Candi, E., Schmidt, R., Melino, G., The cornified envelope: A model of cell death in the skin (2005) Nature Reviews Molecular Cell Biology, 6 (4), pp. 328-340. , DOI 10.1038/nrm1619; Yamaoka, T., Takahashi, Y., Fujisato, T., Lee, C.W., Tsuji, T., Ohta, T., Murakami, A., Kimura, Y., Novel adhesion prevention membrane based on a bioresorbable copoly(ester-ether) comprised of poly-l-lactide and pluronic®: In vitro and in vivo evaluations (2001) Journal of Biomedical Materials Research, 54 (4), pp. 470-479. , DOI 10.1002/1097-4636(20010315)54:4<470::AID-JBM20>3.0.CO;2-X; 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Abd-El-Aleem, S.A., Ferguson, M.W.J., Appleton, I., Kairsingh, S., Jude, E.B., Jones, K., McCollum, C.N., Ireland, G.W., Expression of nitric oxide synthase isoforms and arginase in normal human skin and chronic venous leg ulcers (2000) Journal of Pathology, 191 (4), pp. 434-442; Rojkind, M., Dominguez-Rosales, J.-A., Nieto, N., Greenwel, P., Role of hydrogen peroxide and oxidative stress in healing responses (2002) Cellular and Molecular Life Sciences, 59 (11), pp. 1872-1891. , DOI 10.1007/PL00012511; Moseley, R., Hilton, J.R., Waddington, R.J., Harding, K.G., Stephens, P., Thomas, D.W., Comparison of oxidative stress biomarker profiles between acute and chronic wound environments (2004) Wound Repair and Regeneration, 12 (4), pp. 419-429. , DOI 10.1111/j.1067-1927.2004.12406.x; Rasik, A.M., Shukla, A., Antioxidant status in delayed healing type of wounds (2000) International Journal of Experimental Pathology, 81 (4), pp. 257-263. , 2-s2.0-0033864199 10.1046/j.1365-2613.2000.00158.x; Gopinath, D., Ahmed, M.R., Gomathi, K., Chitra, K., Sehgal, P.K., Jayakumar, R., Dermal wound healing processes with curcumin incorporated collagen films (2004) Biomaterials, 25 (10), pp. 1911-1917. , DOI 10.1016/S0142-9612(03)00625-2; 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PY - 2012
Y1 - 2012
N2 - We examined the effects of vitamin C in Pluronic F127 on diabetic wound healing. Full-thickness excision skin wounds were made in normal and diabetic Wistar rats to evaluate the effect of saline, saline plus vitamin C (antioxidant sol), Pluronic F127, or Pluronic F127 plus vitamin C (antioxidant sol-gel). The rate of wound contraction, the levels of epidermal and dermal maturation, collagen synthesis, and apoptosis production in the wound tissue were determined. In vitro data showed that after 6 hours of air exposure, the order of the scavenging abilities for HOCl, H 2 O 2, and O 2 - was antioxidant sol-gel > antioxidant saline > Pluronic F127 = saline. After 7 and 14 days of wound injury, the antioxidant sol-gel improved wound healing significantly by accelerated epidermal and dermal maturation, an increase in collagen content, and a decrease in apoptosis formation. However, the wounds of all treatments healed mostly at 3 weeks. Vitamin C in Pluronic F127 hastened cutaneous wound healing by its antioxidant and antiapoptotic mechanisms through a good drug delivery system. This study showed that Pluronic F127 plus vitamin C could potentially be employed as a novel wound-healing enhancer. © 2012 Yen-Hsien Lee et al.
AB - We examined the effects of vitamin C in Pluronic F127 on diabetic wound healing. Full-thickness excision skin wounds were made in normal and diabetic Wistar rats to evaluate the effect of saline, saline plus vitamin C (antioxidant sol), Pluronic F127, or Pluronic F127 plus vitamin C (antioxidant sol-gel). The rate of wound contraction, the levels of epidermal and dermal maturation, collagen synthesis, and apoptosis production in the wound tissue were determined. In vitro data showed that after 6 hours of air exposure, the order of the scavenging abilities for HOCl, H 2 O 2, and O 2 - was antioxidant sol-gel > antioxidant saline > Pluronic F127 = saline. After 7 and 14 days of wound injury, the antioxidant sol-gel improved wound healing significantly by accelerated epidermal and dermal maturation, an increase in collagen content, and a decrease in apoptosis formation. However, the wounds of all treatments healed mostly at 3 weeks. Vitamin C in Pluronic F127 hastened cutaneous wound healing by its antioxidant and antiapoptotic mechanisms through a good drug delivery system. This study showed that Pluronic F127 plus vitamin C could potentially be employed as a novel wound-healing enhancer. © 2012 Yen-Hsien Lee et al.
KW - ascorbic acid
KW - collagen
KW - poloxamer
KW - sodium chloride
KW - antioxidant
KW - hydroxyproline
KW - reactive oxygen metabolite
KW - streptozocin
KW - animal cell
KW - animal experiment
KW - animal model
KW - animal tissue
KW - antioxidant activity
KW - apoptosis
KW - article
KW - collagen synthesis
KW - controlled study
KW - dermis
KW - drug delivery system
KW - drug effect
KW - epidermis
KW - female
KW - in vitro study
KW - nonhuman
KW - priority journal
KW - protein content
KW - rat
KW - skin injury
KW - streptozocin diabetes
KW - tissue regeneration
KW - wound contraction
KW - wound healing
KW - animal
KW - chemistry
KW - experimental diabetes mellitus
KW - immunohistochemistry
KW - metabolism
KW - methodology
KW - pathology
KW - pathophysiology
KW - phase transition
KW - skin
KW - time
KW - Wistar rat
KW - Animals
KW - Antioxidants
KW - Apoptosis
KW - Ascorbic Acid
KW - Diabetes Mellitus, Experimental
KW - Drug Delivery Systems
KW - Female
KW - Hydroxyproline
KW - Immunohistochemistry
KW - Phase Transition
KW - Poloxamer
KW - Rats
KW - Rats, Wistar
KW - Reactive Oxygen Species
KW - Skin
KW - Streptozocin
KW - Time Factors
KW - Wound Healing
U2 - 10.1155/2012/504693
DO - 10.1155/2012/504693
M3 - Article
SN - 1687-5214
VL - 2012
JO - Experimental Diabetes Research
JF - Experimental Diabetes Research
ER -