Antioxidant and amine oxidase inhibitory activities of hydroxyurea

Yuh Hwa Liu, Wen Chun Wu, Yeh Lin Lu, Ying Jang Lai, Wen Chi Hou

研究成果: 雜誌貢獻文章同行評審

17 引文 斯高帕斯(Scopus)

摘要

Hydroxyurea (HU, NH2CONHOH), or hydroxycar- bamide, is a hydroxamic acid derivative used as a drug for anti-neoplasm and sickle-cell disease. In this study, HU was found to have antioxidant activities against 2,2- diphenyl-1-picrylhydrazyl (DPPH) and hydroxyl radicals and dose-dependent inhibitory activities against monoamine oxidase (MAO)-A, MAO-B, and semicar- bazide-sensitive amine oxidase (SSAO) as compared to controls of clorgyline, deprenyl, and semicarbazide respectively. HU showed mixed-type, competitive-type, and competitive-type inhibition, respectively, with respect to substrates of MAO-A, MAO-B, and SSAO with apparent inhibition constants (Ki) of 19.46, 5.38, and 1.84 μM.

原文英語
頁(從 - 到)1256-1260
頁數5
期刊Bioscience, Biotechnology and Biochemistry
74
發行號6
DOIs
出版狀態已發佈 - 2010

ASJC Scopus subject areas

  • 生物技術
  • 生物化學
  • 分子生物學
  • 應用微生物與生物技術
  • 分析化學
  • 有機化學
  • 一般醫學

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