TY - JOUR
T1 - Antioxidant and amine oxidase inhibitory activities of hydroxyurea
AU - Liu, Yuh Hwa
AU - Wu, Wen Chun
AU - Lu, Yeh Lin
AU - Lai, Ying Jang
AU - Hou, Wen Chi
PY - 2010
Y1 - 2010
N2 - Hydroxyurea (HU, NH2CONHOH), or hydroxycar- bamide, is a hydroxamic acid derivative used as a drug for anti-neoplasm and sickle-cell disease. In this study, HU was found to have antioxidant activities against 2,2- diphenyl-1-picrylhydrazyl (DPPH) and hydroxyl radicals and dose-dependent inhibitory activities against monoamine oxidase (MAO)-A, MAO-B, and semicar- bazide-sensitive amine oxidase (SSAO) as compared to controls of clorgyline, deprenyl, and semicarbazide respectively. HU showed mixed-type, competitive-type, and competitive-type inhibition, respectively, with respect to substrates of MAO-A, MAO-B, and SSAO with apparent inhibition constants (Ki) of 19.46, 5.38, and 1.84 μM.
AB - Hydroxyurea (HU, NH2CONHOH), or hydroxycar- bamide, is a hydroxamic acid derivative used as a drug for anti-neoplasm and sickle-cell disease. In this study, HU was found to have antioxidant activities against 2,2- diphenyl-1-picrylhydrazyl (DPPH) and hydroxyl radicals and dose-dependent inhibitory activities against monoamine oxidase (MAO)-A, MAO-B, and semicar- bazide-sensitive amine oxidase (SSAO) as compared to controls of clorgyline, deprenyl, and semicarbazide respectively. HU showed mixed-type, competitive-type, and competitive-type inhibition, respectively, with respect to substrates of MAO-A, MAO-B, and SSAO with apparent inhibition constants (Ki) of 19.46, 5.38, and 1.84 μM.
KW - Antioxidant activity
KW - Hydroxyurea (HU)
KW - Monoamine oxidase (MAO)
KW - Semicarbaitive amine oxidase (SSAO)
UR - http://www.scopus.com/inward/record.url?scp=77953975708&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77953975708&partnerID=8YFLogxK
U2 - 10.1271/bbb.100096
DO - 10.1271/bbb.100096
M3 - Article
C2 - 20530901
AN - SCOPUS:77953975708
SN - 0916-8451
VL - 74
SP - 1256
EP - 1260
JO - Bioscience, Biotechnology and Biochemistry
JF - Bioscience, Biotechnology and Biochemistry
IS - 6
ER -