TY - JOUR
T1 - Antimicrobial susceptibility profiles of Gram-negative bacilli isolated from patients with hepatobiliary infections in Taiwan
T2 - Results from the Study for Monitoring Antimicrobial Resistance Trends (SMART), 2006-2010
AU - Toh, Han Siong
AU - Chuang, Yin Ching
AU - Huang, Chi Chang
AU - Lee, Yu Lin
AU - Liu, Yuag Meng
AU - Ho, Cheng Mao
AU - Lu, Po Liang
AU - Liu, Chun Eng
AU - Chen, Yen Hsu
AU - Wang, Jen Hsien
AU - Ko, Wen Chien
AU - Yu, Kwok Woon
AU - Liu, Yung Ching
AU - Chen, Yao Shen
AU - Tang, Hung Jen
AU - Hsueh, Po Ren
PY - 2012/6
Y1 - 2012/6
N2 - We investigated the trends in antimicrobial resistance among species of Gram-negative bacilli isolated from patients with hepatobiliary tract infections in Taiwan during the period 2006-2010 as part of the Study for Monitoring Antimicrobial Resistance Trends (SMART). During the study period, 1032 isolates of Gram-negative bacilli that had been collected from patients with hepatobiliary infections were tested for susceptibility to 12 antimicrobial agents in accordance with the Clinical and Laboratory Standards Institute guidelines. Enterobacteriaceae accounted for the majority (n = 874, 84.7) of isolates and Escherichia coli was the most common pathogen (n = 323, 31.3). There were significantly more E. coli (P = 0.001) and Proteus mirabilis (P = 0.031) isolates collected from patients who had been hospitalized for less than 48 h and significantly more Serratia marcescens (P = 0.035) and Pseudomonas aeruginosa (P = 0.008) isolates collected from patients who had been hospitalized for 48 h or longer. The prevalence of extended-spectrum β-lactamase (ESBL)-producing pathogens was low. The decline in susceptibility rates with time was remarkable for ceftazidime (P = 0.036), ciprofloxacin (P = 0.029), and levofloxacin (P = 0.018). The most effective antibiotics, i.e., those that were active against more than 90 of Enterobacteriaceae, were amikacin, cefepime, imipenem, ertapenem, and piperacillin-tazobactam. Susceptibility of P. aeruginosa to anti-pseudomonal agents was greater than 80. In this study, we found an overall increase in resistance to antimicrobial agents among Gram-negative bacilli isolated from patients with hepatobiliary tract infections in Taiwan. Surveillance of antimicrobial susceptibility and updates of treatment guidelines are recommended to help achieve optimal therapy for patients with hepatobiliary infections.
AB - We investigated the trends in antimicrobial resistance among species of Gram-negative bacilli isolated from patients with hepatobiliary tract infections in Taiwan during the period 2006-2010 as part of the Study for Monitoring Antimicrobial Resistance Trends (SMART). During the study period, 1032 isolates of Gram-negative bacilli that had been collected from patients with hepatobiliary infections were tested for susceptibility to 12 antimicrobial agents in accordance with the Clinical and Laboratory Standards Institute guidelines. Enterobacteriaceae accounted for the majority (n = 874, 84.7) of isolates and Escherichia coli was the most common pathogen (n = 323, 31.3). There were significantly more E. coli (P = 0.001) and Proteus mirabilis (P = 0.031) isolates collected from patients who had been hospitalized for less than 48 h and significantly more Serratia marcescens (P = 0.035) and Pseudomonas aeruginosa (P = 0.008) isolates collected from patients who had been hospitalized for 48 h or longer. The prevalence of extended-spectrum β-lactamase (ESBL)-producing pathogens was low. The decline in susceptibility rates with time was remarkable for ceftazidime (P = 0.036), ciprofloxacin (P = 0.029), and levofloxacin (P = 0.018). The most effective antibiotics, i.e., those that were active against more than 90 of Enterobacteriaceae, were amikacin, cefepime, imipenem, ertapenem, and piperacillin-tazobactam. Susceptibility of P. aeruginosa to anti-pseudomonal agents was greater than 80. In this study, we found an overall increase in resistance to antimicrobial agents among Gram-negative bacilli isolated from patients with hepatobiliary tract infections in Taiwan. Surveillance of antimicrobial susceptibility and updates of treatment guidelines are recommended to help achieve optimal therapy for patients with hepatobiliary infections.
KW - Enterobacteriaceae
KW - Gram-negative bacilli
KW - Hepatobiliary tract infections
KW - Study for Monitoring Antimicrobial Resistance Trends
UR - http://www.scopus.com/inward/record.url?scp=84863454021&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84863454021&partnerID=8YFLogxK
U2 - 10.1016/S0924-8579(12)70005-5
DO - 10.1016/S0924-8579(12)70005-5
M3 - Article
C2 - 22749054
AN - SCOPUS:84863454021
SN - 0924-8579
VL - 40
SP - S18-S23
JO - International Journal of Antimicrobial Agents
JF - International Journal of Antimicrobial Agents
IS - SUPPL. 1
ER -
