TY - JOUR
T1 - Antihypertensive effects of Undaria pinnatifida (wakame) peptide on blood pressure in spontaneously hypertensive rats
AU - Suetsuna, Kunio
AU - Maekawa, Keisei
AU - Chen, Jiun Rong
PY - 2004/5
Y1 - 2004/5
N2 - We examined the angiotensin I-converting enzyme (ACE) inhibitory activity and antihypertensive effect of the hot water extract of wakame, Undaria pinnatifida. Ten dipeptides were isolated from the extract by several steps of chromatography, and their amino acid sequences were Tyr-His, Lys-Trp, Lys-Tyr, Lys-Phe, Phe-Tyr, Val-Trp, Val-Phe, Ile-Tyr, Ile-Trp, and Val-Tyr. Both single administration and repeated oral administration of synthetic Tyr-His, Lys-Tyr, Phe-Tyr, and Ile-Tyr significantly decreased blood pressure in spontaneously hypertensive rats.
AB - We examined the angiotensin I-converting enzyme (ACE) inhibitory activity and antihypertensive effect of the hot water extract of wakame, Undaria pinnatifida. Ten dipeptides were isolated from the extract by several steps of chromatography, and their amino acid sequences were Tyr-His, Lys-Trp, Lys-Tyr, Lys-Phe, Phe-Tyr, Val-Trp, Val-Phe, Ile-Tyr, Ile-Trp, and Val-Tyr. Both single administration and repeated oral administration of synthetic Tyr-His, Lys-Tyr, Phe-Tyr, and Ile-Tyr significantly decreased blood pressure in spontaneously hypertensive rats.
KW - Angiotensin converting enzyme
KW - blood pressure
KW - Dipeptide
KW - Hot water extract
KW - Wakame
UR - http://www.scopus.com/inward/record.url?scp=2342590572&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=2342590572&partnerID=8YFLogxK
U2 - 10.1016/j.jnutbio.2003.11.004
DO - 10.1016/j.jnutbio.2003.11.004
M3 - Article
C2 - 15135150
AN - SCOPUS:2342590572
SN - 0955-2863
VL - 15
SP - 267
EP - 272
JO - Journal of Nutritional Biochemistry
JF - Journal of Nutritional Biochemistry
IS - 5
ER -
