Antibiotic usage in community-acquired infections in hospitals in Taiwan

Monto Ho, Feng Yee Chang, Hsiao Chuan Yin, Ren Jy Ben, Luan Yin Chang, Po Yen Chen, Shu Hsing Cheng, Shu Ting Chen, Fang Liang Huang, Hsiu Chen Lin, Daniel C T Lu, Ning Chi Wang, Jann Tay Wang

研究成果: 雜誌貢獻文章同行評審

9 引文 斯高帕斯(Scopus)


Background and Purpose: Using an epidemiologically meaningful in-hospital population with community-acquired infections, we evaluated antibiotic therapy in terms of indication and choice of antibiotic and microbiologic work-up. Methods: Infectious disease specialists evaluated charts of 436 patients from 9 hospitals and selected those who received antibiotics within 3 days of admission. Each antibiotic prescribed was marked for appropriateness of indication and choice. Microbiologic isolates were evaluated for their clinical significance. Results: The most common infections were in the lower respiratory tract (46.1%). Each patient received a mean of 2.25 antibiotics for 8.1 ± 6.4 days. Of the 975 courses of antibiotics given in the study period, indication and choice were correct in 37.4% and unsatisfactory in 14.5%. The vast majority of antibiotics used (79.2%) were first-line antibiotics - usually first-generation cephalosporins, aminoglycosides, and aminopenicillins. Most patients (66%) had a microbiology laboratory work-up, but only 37.4% were judged by evaluators to have a meaningful microbiologic diagnosis. Among the 201 patients with lower respiratory tract infections, 105 (52.2%) had a diagnosis of pneumonia. A positive isolate was recovered in 30 (28.6%) patients, and most of these isolates (20,68.7%) were aerobic gram-negative rods. There were three positive blood cultures but none grew Streptococcus pneumoniae. Conclusions: Antibiotics were used excessively in number and duration. The microbiologic work-up had little effect on the indication and choice of antibiotics. Community-acquired pneumonia differed markedly from that in Western countries in that only 3.3% were caused by S. pneumoniae.
頁(從 - 到)34-42
期刊Journal of the Formosan Medical Association
出版狀態已發佈 - 2002

ASJC Scopus subject areas

  • 一般醫學


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