Anti-neutrophil cytoplasmic autoantibody-associated vasculitides

Shih Yu Lee, Hon Pin Wang, Tsung Hsien Chen, Peir Haur Hung, Kuan Yu Hung

研究成果: 雜誌貢獻文章同行評審

摘要

Although antineutrophil cytoplasm antibody (ANCA)-associated vasculitides (AAV) rarity and still unknown causes, research on those vasculitides has been very active over the past few decades. AAV are small-vessel vasculitides and the clinical symptoms vary and affect several organs, such as the kidney and lung. AAV is similar to other autoimmune diseases and develops in patients with a predisposing genetic background who have been exposed to causative environmental factors. AAV pathogenic mechanisms should explain the pathologic and clinical manifestations of AAV, which involves ANCA-mediated neutrophil overactivations that subsequently release inflammatory cytokines. AAV clinical diagnosis and treatment should avoid delay to prevent end organ damage, particularly renal disease. Adverse responses to treatment AAV are common, as are relapses, so requiring long term follow-up is needed.
原文英語
頁(從 - 到)91-105
頁數15
期刊Journal of Internal Medicine of Taiwan
31
發行號2
DOIs
出版狀態已發佈 - 4月 2020
對外發佈

ASJC Scopus subject areas

  • 內科學

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