Anti-inflammatory constituents from a sea anemone-derived fungus Arthrinium arundinis MA30

Yuen Sing Lee, Ho Cheng Wu, Shu Jung Huang, George Hsiao, Wei Chiung Chi, Tzong Huei Lee

研究成果: 雜誌貢獻文章同行評審

摘要

In this study, preliminary field-sampling of bioactive fungal strains and bioassay-guided selection were conducted. A number of fungal strains were isolated from sea anemones along the northeastern coast of Badouzi, Keelung, Taiwan. Among them, Arthrinium arundinis MA30 showed significant anti-inflammatory activity and was thus selected for further chemical investigation. After a series of purification and isolation using different chromatographic techniques on the fermented products of A. arundinis MA30, thirty-one compounds were identified, five of which were previously unreported, including arthrinoic acid, hexylaconitic anhydride methyl ester, (3S,8R)-8-hydroxy-3-carboxy-2-methylenenonanoic acid, and arthripenoids G and H. These compounds were subjected to comprehensive spectroscopic data analysis. Of all the isolates, 1,3,5,6-tetrahydroxy-8-methylxanthone and arthripenoid C demonstrated the most distinctive inhibitory activities against nitric oxide production in mouse microglial BV-2 cells, with their respective inhibitory rates being 71% and 81% at 10 μM concentration, and their respective IC50 values were further determined to be 5.3 ± 0.6 and 1.6 ± 0.4 μM. These compounds showed no significant cytotoxicity, and curcumin was used as a positive control in this study.
原文英語
文章編號113998
期刊Phytochemistry
219
DOIs
出版狀態已發佈 - 3月 2024

ASJC Scopus subject areas

  • 生物化學
  • 分子生物學
  • 植物科學
  • 園藝科學

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