@article{c42e5dd7da8440b9950ae52efed47fc3,
title = "Anti-inflammatory cembrane-based diterpenoids isolated from the octocoral Sinularia querciformis",
abstract = "The exploration of Sinularia querciformis cembranoids afforded two new compounds, querciformolide G (1) and H (2), along with three known ones, sinulaparvalide (3), sinulariolone acetate (4), and 3,4:8,11-bisepoxy-7-hydroxycembra-15(17)-en-1,12-olide (5). The structural elucidation of these compounds was achieved by extensive spectroscopic (IR, ESIMS, 1D and 2D NMR data) analysis and by comparison with those previously reported in the literature. Compounds 1–5 were evaluated for their anti-inflammatory activity. Among all, compound 1 displayed significant inhibitory effects on the elastase release in activated human neutrophils.",
keywords = "Anti-inflammation, Cembranoid, Elastase release, Sinularia querciformis",
author = "Kung, {Te An} and Chen, {Lo Yun} and Li, {Chia Ying} and Peng, {Bo Rong} and Hwang, {Tsong Long} and Sung, {Ping Jyun} and Lai, {Kuei Hung} and Chung, {Hsu Ming}",
note = "Funding Information: This research was supported by the grants from the National Pingtung University and the National Science and Technology Council , Taiwan (Grant No.: MOST 110-2320-B-153-001 ) awarded to Hsu-Ming Chung; by the grant from the National Science and Technology Council ( MOST 110-2320-B-038-034, MOST 111-2320-B-038-040-MY3; MOST 111-2321-B-255-001 ), Ministry of Education ( DP2-110-21121-01-N-12-03 ), and Taipei Medical University ( TMU109-AE1-B15 ) awarded to Kuei-Hung Lai. The authors are thankful the High Val-ued Instrument Center, National Sun Yat-sen University , for the mass ( MS000600 ) and NMR ( NMR001100 ) spectra ( MOST 110-2731-M-110-001 ). Funding Information: This research was supported by the grants from the National Pingtung University and the National Science and Technology Council, Taiwan (Grant No.: MOST 110-2320-B-153-001) awarded to Hsu-Ming Chung; by the grant from the National Science and Technology Council (MOST 110-2320-B-038-034, MOST 111-2320-B-038-040-MY3; MOST 111-2321-B-255-001), Ministry of Education (DP2-110-21121-01-N-12-03), and Taipei Medical University (TMU109-AE1-B15) awarded to Kuei-Hung Lai. The authors are thankful the High Val-ued Instrument Center, National Sun Yat-sen University, for the mass (MS000600) and NMR (NMR001100) spectra (MOST 110-2731-M-110-001). Publisher Copyright: {\textcopyright} 2023 Phytochemical Society of Europe",
year = "2023",
month = jun,
doi = "10.1016/j.phytol.2023.03.004",
language = "English",
volume = "55",
pages = "12--16",
journal = "Phytochemistry Letters",
issn = "1874-3900",
publisher = "Elsevier BV",
}