TY - JOUR
T1 - Annual influenza vaccination reduces total hospitalization in patients with chronic hepatitis B virus infection
T2 - A population-based analysis
AU - Su, Fu Hsiung
AU - Huang, Ya Li
AU - Sung, Fung Chang
AU - Su, Chien Tien
AU - Hsu, Wen Hsin
AU - Chang, Shih Ni
AU - Yeh, Chih Ching
N1 - Funding Information:
This work was funded by Taipei Medical University Hospital ( 101TMU-TMUH-13 ), Taipei Medical University – National Taiwan University of Science and Technology Joint Research Program (TMU-NTUST-103-11), and Taiwan Ministry of Health and Welfare Clinical Trial and Research Center of Excellence ( MOHW103-TDU-B-212-113002 ).
Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2016/1/2
Y1 - 2016/1/2
N2 - Background: This study evaluated hospitalization and mortality in patients with chronic hepatitis B virus infection (HBV (+)) and matched comparison patients after stratifying the patients according to annual influenza vaccination (Vaccine (+)). Methods: Data from Taiwan's National Health Insurance program from 2000 to 2009 were used to identify HBV(+)/vaccine(+) (n=4434), HBV(+)/Vaccine(-) (n=3646), HBV(-)/Vaccine(+) (n=8868), and HBV(-)/Vaccine(-) (n=8868) cohorts. The risk of pneumonia/influenza, respiratory failure, intensive care, hospitalization, and mortality in the four cohorts was evaluated. Results: The total hospitalization rate was significantly lower in patients with chronic HBV infection who received an annual influenza vaccination than in chronic HBV-infected patients who did not receive an influenza vaccination (16.29 vs. 24.02 per 100 person-years), contributing to an adjusted hazard ratio (HR) of 0.56 (95% confidence interval (CI). =0.50-0.62). The HBV(+)/Vaccine(+) cohort also had lower risks than the HBV(+)/Vaccine(-) cohort for pneumonia and influenza (adjusted HR. =0.79, 95% CI. =0.67-0.92), intensive care unit admission (adjusted HR. =0.33, 95% CI. =0.25-0.43), and mortality (adjusted HR. =0.19, 95% CI. =0.15-0.24). Conclusions: Our results suggest that annual influenza vaccination can reduce the risk of hospitalization and mortality in patients with chronic HBV infection.
AB - Background: This study evaluated hospitalization and mortality in patients with chronic hepatitis B virus infection (HBV (+)) and matched comparison patients after stratifying the patients according to annual influenza vaccination (Vaccine (+)). Methods: Data from Taiwan's National Health Insurance program from 2000 to 2009 were used to identify HBV(+)/vaccine(+) (n=4434), HBV(+)/Vaccine(-) (n=3646), HBV(-)/Vaccine(+) (n=8868), and HBV(-)/Vaccine(-) (n=8868) cohorts. The risk of pneumonia/influenza, respiratory failure, intensive care, hospitalization, and mortality in the four cohorts was evaluated. Results: The total hospitalization rate was significantly lower in patients with chronic HBV infection who received an annual influenza vaccination than in chronic HBV-infected patients who did not receive an influenza vaccination (16.29 vs. 24.02 per 100 person-years), contributing to an adjusted hazard ratio (HR) of 0.56 (95% confidence interval (CI). =0.50-0.62). The HBV(+)/Vaccine(+) cohort also had lower risks than the HBV(+)/Vaccine(-) cohort for pneumonia and influenza (adjusted HR. =0.79, 95% CI. =0.67-0.92), intensive care unit admission (adjusted HR. =0.33, 95% CI. =0.25-0.43), and mortality (adjusted HR. =0.19, 95% CI. =0.15-0.24). Conclusions: Our results suggest that annual influenza vaccination can reduce the risk of hospitalization and mortality in patients with chronic HBV infection.
KW - Hepatitis B virus
KW - Influenza
KW - Population-based study
KW - Vaccination
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U2 - 10.1016/j.vaccine.2015.10.129
DO - 10.1016/j.vaccine.2015.10.129
M3 - Article
C2 - 26614589
AN - SCOPUS:84949730237
SN - 0264-410X
VL - 34
SP - 120
EP - 127
JO - Vaccine
JF - Vaccine
IS - 1
ER -
