Animal models and in vivo investigations for drug repurposing in lung cancer

Hsuen Wen Kate Chang, Vincent H.S. Chang

研究成果: 書貢獻/報告類型章節

2 引文 斯高帕斯(Scopus)


Lung cancer is the leading cause of cancer deaths worldwide. The difficulties of early detection and treatment resistance adversely affect prognosis. Major challenges for new drug development include cost, safety, and efficacy. As a result, repurposing existing drugs for new indications offers a more favorable risk-return trade-off than other available drug development strategies. Numerous mouse models for lung cancer have been established, which can primarily be divided into genetically engineered or xenograft mouse models. However, genetically modulated models cannot fully represent the systemic complexity of lung cancer, and xenograft models do not behave identically to human lung tumors in drug repurposing. This chapter reviews the current animal models in lung cancer drug repurposing and assesses the challenges and future directions of this field.

主出版物標題Drug Repurposing in Cancer Therapy
主出版物子標題Approaches and Applications
出版狀態已發佈 - 1月 1 2020

ASJC Scopus subject areas

  • 一般農業與生物科學
  • 一般生物化學,遺傳學和分子生物學


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