@article{39263eeaaa784fa59be073eb2ad3db94,
title = "ANGPTL2 promotes VEGF-A synthesis in human lung cancer and facilitates lymphangiogenesis",
abstract = "Lung cancer is an extremely common cancer and metastatic lung cancer has a greatly low survival rate. Lymphangiogenesis is essential for the development and metastasis of lung cancer. The adipokine angiopoietin-like protein 2 (ANGPTL2) regulates tumor progression and metastasis, although the functions of ANGPTL2 in lung cancer are unknown. Analysis of data from TCGA genomics program, the GEPIA web server and the Oncomine database revealed that higher levels of ANGPTL2 expression were correlated with progressive disease and lymph node metastasis. ANGPTL2 enhanced VEGF-A-dependent lymphatic endothelial cell (LEC) tube formation and migration. Integrin α5β1, p38 and nuclear factor (NF)-κB signaling mediated ANGPTL2-regulated lymphangiogenesis. Importantly, overexpression ANGPTL2 facilitated tumor growth and lymphangiogenesis in vivo.",
keywords = "ANGPTL2, LEC, lung cancer, lymphangiogenesis, VEGF-A",
author = "Liu, {Po I.} and Jiang, {Ya Jing} and Chang, {An Chen} and Huang, {Chang Lun} and Fong, {Yi Chin} and Guo, {Jeng Hung} and Liu, {Chun Lin} and Wang, {Shih Wei} and Liu, {Ju Fang} and Chang, {Sunny Li Yu} and Tang, {Chih Hsin}",
note = "Funding Information: This study was supported by grants from Taiwan{\textquoteright}s Ministry of Science and Technology (MOST 110-2320-B-039-022-MY3); China Medical University Hospital (DMR-111-164; DMR-111-108; DMR-111-229; DMR-112-077; DMR-112-081); Asia University Hospital (11051008); Changhua Christian Hospital (108-CCH-IRP-028; National Science and Technology Council (NSTC 111-2320-B-468-006-). Publisher Copyright: {\textcopyright} 2023 Liu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited",
year = "2023",
doi = "10.18632/aging.204581",
language = "English",
volume = "15",
pages = "1652--1667",
journal = "Aging",
issn = "1945-4589",
publisher = "US Administration on Aging",
number = "5",
}
