Angiopoietin-like protein 1 suppresses SLUG to inhibit cancer cell motility

Tsang Chih Kuo, Ching Ting Tan, Yi Wen Chang, Chih Chen Hong, Wei Jiunn Lee, Min Wei Chen, Yung Ming Jeng, Jean Chiou, Pei Yu, Pai Sheng Chen, Ming Yang Wang, Michael Hsiao, Jen Liang Su, Min Liang Kuo

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71 引文 斯高帕斯(Scopus)


Angiopoietin-like protein 1 (ANGPTL1) is a potent regulator of angiogenesis. Growing evidence suggests that ANGPTL family proteins not only target endothelial cells but also affect tumor cell behavior. In a screen of 102 patients with lung cancer, we found that ANGPTL1 expression was inversely correlated with invasion, lymph node metastasis, and poor clinical outcomes. ANGPTL1 suppressed the migratory, invasive, and metastatic capabilities of lung and breast cancer cell lines in vitro and reduced metastasis in mice injected with cancer cell lines overexpressing ANGPTL1. Ectopic expression of ANGPTL1 suppressed the epithelial-to-mesenchymal transition (EMT) by reducing the expression of the zinc-finger protein SLUG. A microRNA screen revealed that ANGPTL1 suppressed SLUG by inducing expression of miR-630 in an integrin α1β1/FAK/ERK/SP1 pathway-dependent manner. These results demonstrate that ANGPTL1 represses lung cancer cell motility by abrogating the expression of the EMT mediator SLUG.
頁(從 - 到)1082-1095
期刊Journal of Clinical Investigation
出版狀態已發佈 - 3月 1 2013

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